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Genetically modified crops

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</style><div role="note" class="hatnote navigation-not-searchable">"GM Crops" redirects here. For the journal formerly printed under that name, see <a href="GM_Crops_%26_Food" title="GM Crops & Food">GM Crops & Food</a>.</div>

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</style><table class="sidebar nomobile nowraplinks hlist"><tbody><tr><td class="sidebar-pretitle" style="padding-bottom:0.15em;">Part of a series on</td></tr><tr><th class="sidebar-title-with-pretitle" style="font-size:175%;padding-top:0.2em;font-weight:normal;"><a href="Genetic_engineering" title="Genetic engineering">Genetic engineering</a></th></tr><tr><td class="sidebar-image"></td></tr><tr><td class="sidebar-content" style="padding:0.2em 0.4em 0.4em;;background:none;font-size:40%;line-height:0.4em;">

</td>

</tr><tr><th class="sidebar-heading">

<a href="Genetically_modified_organism" title="Genetically modified organism">Genetically modified organisms</a></th></tr><tr><td class="sidebar-content" style="padding:0.2em 0.4em 0.4em;">

<ul><li><a href="Genetically_modified_bacteria" title="Genetically modified bacteria">Bacteria</a></li>

<li><a href="Genetically_modified_virus" title="Genetically modified virus">Viruses</a></li></ul>

<ul><li><a href="Genetically_modified_animal" title="Genetically modified animal">Animals</a>

<ul><li><a href="Genetically_modified_mammal" title="Genetically modified mammal">Mammals</a></li>

<li><a href="Genetically_modified_insect" title="Genetically modified insect">Insects</a></li></ul></li></ul>

<ul><li><a href="Genetically_modified_plant" title="Genetically modified plant">Plants</a>

<ul><li><a href="Genetically_modified_maize" title="Genetically modified maize">Maize/corn</a></li>

<li><a href="Genetically_modified_soybean" title="Genetically modified soybean">Soybean</a></li>

<li><a href="Genetically_modified_potato" title="Genetically modified potato">Potato</a></li></ul></li></ul></td>

</tr><tr><th class="sidebar-heading">

History and regulation</th></tr><tr><td class="sidebar-content" style="padding:0.2em 0.4em 0.4em;">

<ul><li><a href="History_of_genetic_engineering" title="History of genetic engineering">History</a></li></ul>

<ul><li><a href="Regulation_of_genetic_engineering" title="Regulation of genetic engineering">Regulation</a>

<ul><li><a href="Substantial_equivalence" title="Substantial equivalence">Substantial equivalence</a></li>

<li><a href="Cartagena_Protocol_on_Biosafety" title="Cartagena Protocol on Biosafety">Cartagena Protocol on Biosafety</a></li></ul></li></ul></td>

</tr><tr><th class="sidebar-heading">

Process</th></tr><tr><td class="sidebar-content" style="padding:0.2em 0.4em 0.4em;">

<ul><li><a href="Genetic_engineering_techniques" title="Genetic engineering techniques">Techniques</a></li>

<li><a href="Molecular_cloning" title="Molecular cloning">Molecular cloning</a>

<ul><li><a href="Recombinant_DNA" title="Recombinant DNA">Recombinant DNA</a></li></ul></li>

<li><a href="Gene_delivery" title="Gene delivery">Gene delivery</a>

<ul><li><a href="Transformation_(genetics)" class="mw-redirect" title="Transformation (genetics)">Transformation</a></li>

<li><a href="Transfection" title="Transfection">Transfection</a></li>

<li><a href="Transduction_(genetics)" title="Transduction (genetics)">Transduction</a></li></ul></li>

<li><a href="Genome_editing" title="Genome editing">Genome editing</a>

<ul><li><a href="TALEN" class="mw-redirect" title="TALEN">TALEN</a></li>

<li><a href="CRISPR" title="CRISPR">CRISPR</a></li></ul></li></ul></td>

</tr><tr><th class="sidebar-heading">

Applications</th></tr><tr><td class="sidebar-content" style="padding:0.2em 0.4em 0.4em;">

<li><a href="Gene_therapy" title="Gene therapy">Gene therapy</a></li>

<li><a href="Designer_baby" title="Designer baby">Designer baby</a></li></ul></td>

</tr><tr><th class="sidebar-heading">

Controversies</th></tr><tr><td class="sidebar-content" style="padding:0.2em 0.4em 0.4em;">

<ul><li><a href="Genetically_modified_food_controversies" title="Genetically modified food controversies">Genetically modified food controversies</a></li>

<li><a href="GMO_conspiracy_theories" title="GMO conspiracy theories">GMO conspiracy theories</a></li>

<li><a href="Pusztai_affair" title="Pusztai affair">Pusztai affair</a></li>

<li><a href="S%C3%A9ralini_affair" title="Séralini affair">Séralini affair</a></li>

<li><a href="StarLink_corn_recall" title="StarLink corn recall">StarLink corn recall</a></li>

<li><a href="He_Jiankui_affair" title="He Jiankui affair">He Jiankui affair</a></li></ul></td>

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Genetically modified crops (GM crops) are plants used in <a href="Agriculture" title="Agriculture">agriculture</a>, the <a href="DNA" title="DNA">DNA</a> of which has been modified using <a href="Genetic_engineering" title="Genetic engineering">genetic engineering</a> methods. Plant <a href="Genome" title="Genome">genomes</a> can be engineered by physical methods or by use of <a href="Agrobacterium" title="Agrobacterium">Agrobacterium</a> for the delivery of sequences hosted in <a href="Transfer_DNA_binary_system" title="Transfer DNA binary system">T-DNA binary vectors</a>. In most cases, the aim is to introduce a new <a href="Trait_(biology)" class="mw-redirect" title="Trait (biology)">trait</a> to the plant which does not occur naturally in the species. Examples in food crops include resistance to certain pests, diseases, environmental conditions, reduction of spoilage, resistance to chemical treatments (e.g. resistance to a <a href="Herbicide" title="Herbicide">herbicide</a>), or improving the nutrient profile of the crop. Examples in non-food crops include production of <a href="Plant_manufactured_pharmaceuticals" title="Plant manufactured pharmaceuticals">pharmaceutical agents</a>, <a href="Biofuels" class="mw-redirect" title="Biofuels">biofuels</a>, and other industrially useful goods, as well as for <a href="Bioremediation" title="Bioremediation">bioremediation</a>.<a href="#cite_note-James2013-1">[1]</a>

Farmers have widely adopted GM technology. Acreage increased from 1.7 million hectares in 1996 to 185.1 million hectares in 2016, some 12% of global cropland. As of 2016, major crop (<a href="Soybean" title="Soybean">soybean</a>, <a href="Maize" title="Maize">maize</a>, <a href="Canola" class="mw-redirect" title="Canola">canola</a> and <a href="Cotton" title="Cotton">cotton</a>) traits consist of herbicide tolerance (95.9 million hectares) insect resistance (25.2 million hectares), or both (58.5 million hectares). In 2015, 53.6 million ha of <a href="Genetically_modified_maize" title="Genetically modified maize">Genetically modified maize</a> were under cultivation (almost 1/3 of the maize crop). GM maize outperformed its predecessors: yield was 5.6 to 24.5% higher with less <a href="Mycotoxin" title="Mycotoxin">mycotoxins</a> (−28.8%), <a href="Fumonisin_B1" title="Fumonisin B1">fumonisin</a> (−30.6%) and thricotecens (−36.5%). Non-target organisms were unaffected, except for lower populations some <a href="Parasitoid" title="Parasitoid">parasitoid</a> wasps due to decreased populations of their pest host <a href="European_corn_borer" title="European corn borer">European corn borer</a>; European corn borer is a target of <a href="Lepidoptera" title="Lepidoptera">Lepidoptera</a> active Bt maize. Biogeochemical parameters such as lignin content did not vary, while biomass decomposition was higher.<a href="#cite_note-Pellegrino_2018-2">[2]</a>

A 2014 meta-analysis concluded that GM technology adoption had reduced chemical <a href="Pesticide" title="Pesticide">pesticide</a> use by 37%, increased <a href="Crop_yields" class="mw-redirect" title="Crop yields">crop yields</a> by 22%, and increased farmer profits by 68%.<a href="#cite_note-KlumperQaim-3">[3]</a> This reduction in pesticide use has been ecologically beneficial, but benefits may be reduced by overuse.<a href="#cite_note-nytimes.com-4">[4]</a> Yield gains and pesticide reductions are larger for insect-resistant crops than for herbicide-tolerant crops.<a href="#cite_note-perry-5">[5]</a> Yield and profit gains are higher in <a href="Developing_countries" class="mw-redirect" title="Developing countries">developing countries</a> than in <a href="Developed_countries" class="mw-redirect" title="Developed countries">developed countries</a>.<a href="#cite_note-KlumperQaim-3">[3]</a> <a href="Pesticide_poisoning" title="Pesticide poisoning">Pesticide poisonings</a> were reduced by 2.4 to 9 million cases per year in India alone.<a href="#cite_note-Smyth-6">[6]</a> A 2011 review of the relationship between <a href="Farmers'_suicides_in_India#GM_crops" title="Farmers' suicides in India">Bt cotton adoption and farmer suicides in India</a> found that "Available data show no evidence of a 'resurgence' of farmer suicides" and that "Bt cotton technology has been very effective overall in India."<a href="#cite_note-7">[7]</a> During the time period of <a href="Bt_cotton" title="Bt cotton">Bt cotton</a> introduction in India, farmer suicides instead declined by 25%.<a href="#cite_note-Smyth-6">[6]</a>

There is a <a href="Scientific_consensus" title="Scientific consensus">scientific consensus</a><a href="#cite_note-Nicolia2013-8">[8]</a><a href="#cite_note-FAO-9">[9]</a><a href="#cite_note-Ronald2011-10">[10]</a><a href="#cite_note-Also-11">[11]</a> that currently available food derived from GM crops poses no greater risk to human health than conventional food,<a href="#cite_note-AAAS2012-12">[12]</a><a href="#cite_note-ECom2010-13">[13]</a><a href="#cite_note-AMA2001-14">[14]</a><a href="#cite_note-LoC2015-15">[15]</a><a href="#cite_note-NAS2016-16">[16]</a> but that each GM food needs to be tested on a case-by-case basis before introduction.<a href="#cite_note-WHOFAQ-17">[17]</a><a href="#cite_note-Haslberger2003-18">[18]</a><a href="#cite_note-BMA2004-19">[19]</a> Nonetheless, members of the public are much less likely than scientists to perceive GM foods as safe.<a href="#cite_note-PEW2015-20">[20]</a><a href="#cite_note-Marris2001-21">[21]</a><a href="#cite_note-PABE-22">[22]</a><a href="#cite_note-Scott2016-23">[23]</a> The legal and regulatory status of GM foods varies by country, with some nations banning or restricting them, and others permitting them with widely differing degrees of regulation.<a href="#cite_note-loc.gov-24">[24]</a><a href="#cite_note-Bashshur-25">[25]</a><a href="#cite_note-Sifferlin-26">[26]</a><a href="#cite_note-Council_on_Foreign_Relations-27">[27]</a>

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<div class="mw-heading mw-heading2"><h2 id="History">History</h2></div>

<div role="note" class="hatnote navigation-not-searchable">Main article: <a href="History_of_genetic_engineering" title="History of genetic engineering">History of genetic engineering</a></div>

Humans have directly influenced the genetic makeup of plants to increase their value as a crop through <a href="Domestication" title="Domestication">domestication</a>. The first evidence of plant domestication comes from <a href="Emmer" title="Emmer">emmer</a> and <a href="Einkorn_wheat" class="mw-redirect" title="Einkorn wheat">einkorn wheat</a> found in <a href="Pre-Pottery_Neolithic_A" title="Pre-Pottery Neolithic A">pre-Pottery Neolithic A</a> villages in Southwest Asia dated about 10,500 to 10,100 BC.<a href="#cite_note-28">[28]</a> The <a href="Fertile_Crescent" title="Fertile Crescent">Fertile Crescent</a> of Western Asia, <a href="Ancient_Egyptian_Agriculture" class="mw-redirect" title="Ancient Egyptian Agriculture">Egypt</a>, and <a href="History_of_agriculture_in_the_Indian_subcontinent" title="History of agriculture in the Indian subcontinent">India</a> were sites of the earliest planned sowing and harvesting of plants that had previously been gathered in the wild. Independent development of agriculture occurred in northern and southern China, Africa's <a href="Sahel" title="Sahel">Sahel</a>, <a href="New_Guinea" title="New Guinea">New Guinea</a> and several regions of the Americas.<a href="#cite_note-29">[29]</a> The eight <a href="Neolithic_founder_crops" class="mw-redirect" title="Neolithic founder crops">Neolithic founder crops</a> (<a href="Emmer_wheat" class="mw-redirect" title="Emmer wheat">emmer wheat</a>, <a href="Einkorn_wheat" class="mw-redirect" title="Einkorn wheat">einkorn wheat</a>, <a href="Barley" title="Barley">barley</a>, <a href="Peas" class="mw-redirect" title="Peas">peas</a>, <a href="Lentils" class="mw-redirect" title="Lentils">lentils</a>, <a href="Vicia_ervilia" title="Vicia ervilia">bitter vetch</a>, <a href="Chick_pea" class="mw-redirect" title="Chick pea">chick peas</a> and <a href="Flax" title="Flax">flax</a>) had all appeared by about 7,000 BC.<a href="#cite_note-30">[30]</a> Traditional crop breeders have long introduced foreign <a href="Germplasm" title="Germplasm">germplasm</a> into crops by creating novel crosses. A <a href="Hybrid_(biology)" title="Hybrid (biology)">hybrid</a> <a href="Cereal" title="Cereal">cereal</a> grain was created in 1875, by crossing <a href="Genetically_modified_wheat" title="Genetically modified wheat">wheat</a> and <a href="Rye" title="Rye">rye</a>.<a href="#cite_note-31">[31]</a> Since then traits including <a href="Dwarfing" title="Dwarfing">dwarfing genes</a> and <a href="Plant_disease_resistance" title="Plant disease resistance">rust resistance</a> have been introduced in that manner.<a href="#cite_note-32">[32]</a> <a href="Plant_tissue_culture" title="Plant tissue culture">Plant tissue culture</a> and deliberate <a href="Mutation" title="Mutation">mutations</a> have enabled humans to alter the makeup of plant genomes.<a href="#cite_note-33">[33]</a><a href="#cite_note-34">[34]</a>

Modern advances in genetics have allowed humans to more directly alter plants genetics. In 1970 <a href="Hamilton_O._Smith" title="Hamilton O. Smith">Hamilton Smith's</a> lab discovered <a href="Restriction_enzymes" class="mw-redirect" title="Restriction enzymes">restriction enzymes</a> that allowed DNA to be cut at specific places, enabling scientists to isolate genes from an organism's genome.<a href="#cite_note-35">[35]</a> <a href="DNA_ligase" title="DNA ligase">DNA ligases</a> that join broken DNA together had been discovered earlier in 1967,<a href="#cite_note-WeissRichardson1967-36">[36]</a> and by combining the two technologies, it was possible to "cut and paste" DNA sequences and create <a href="Recombinant_DNA" title="Recombinant DNA">recombinant DNA</a>. <a href="Plasmid" title="Plasmid">Plasmids</a>, discovered in 1952,<a href="#cite_note-37">[37]</a> became important <a href="Vector_(molecular_biology)" title="Vector (molecular biology)">tools</a> for transferring information between cells and <a href="Molecular_cloning" title="Molecular cloning">replicating</a> DNA sequences. In 1907 a bacterium that caused plant tumors, <a href="Agrobacterium_tumefaciens" title="Agrobacterium tumefaciens">Agrobacterium tumefaciens</a>, was discovered and in the early 1970s the tumor inducing agent was found to be a DNA plasmid called the <a href="Ti_plasmid" title="Ti plasmid">Ti plasmid</a>.<a href="#cite_note-38">[38]</a> By removing the genes in the plasmid that caused the tumor and adding in novel genes researchers were able to infect plants with A. tumefaciens and let the bacteria insert their chosen DNA sequence into the genomes of the plants.<a href="#cite_note-39">[39]</a> As not all plant cells were susceptible to infection by A. tumefaciens other methods were developed, including <a href="Electroporation" title="Electroporation">electroporation</a>, <a href="Microinjection" title="Microinjection">micro-injection</a><a href="#cite_note-40">[40]</a> and particle bombardment with a <a href="Biolistic_Particle_Delivery_System" class="mw-redirect" title="Biolistic Particle Delivery System">gene gun</a> (invented in 1987).<a href="#cite_note-41">[41]</a><a href="#cite_note-42">[42]</a> In the 1980s techniques were developed to introduce isolated <a href="Chloroplasts" class="mw-redirect" title="Chloroplasts">chloroplasts</a> back into a plant cell that had its cell wall removed. With the introduction of the gene gun in 1987 it became possible to integrate foreign genes into a <a href="Chloroplast" title="Chloroplast">chloroplast</a>.<a href="#cite_note-43">[43]</a> Genetic transformation has become very efficient in some model organisms. In 2008 genetically modified seeds were produced in Arabidopsis thaliana by dipping the flowers in an Agrobacterium solution.<a href="#cite_note-44">[44]</a> In 2013 <a href="CRISPR" title="CRISPR">CRISPR</a> was first used to target modification of plant genomes.<a href="#cite_note-pmid23999092-45">[45]</a>

The first genetically engineered crop plant was tobacco, reported in 1983.<a href="#cite_note-46">[46]</a> It was developed creating a <a href="Chimeric_gene" title="Chimeric gene">chimeric gene</a> that joined an antibiotic resistant gene to the T1 plasmid from Agrobacterium. The tobacco was infected with Agrobacterium transformed with this plasmid resulting in the chimeric gene being inserted into the plant. Through <a href="Tissue_culture" title="Tissue culture">tissue culture</a> techniques a single tobacco cell was selected that contained the gene and a new plant grown from it.<a href="#cite_note-47">[47]</a> The first field trials of <a href="Transgenic_plants" class="mw-redirect" title="Transgenic plants">genetically engineered plants</a> occurred in France and the US in 1986, tobacco plants were engineered to be resistant to <a href="Herbicide" title="Herbicide">herbicides</a>.<a href="#cite_note-James_1996-48">[48]</a> In 1987 <a href="Plant_Genetic_Systems" title="Plant Genetic Systems">Plant Genetic Systems</a>, founded by <a href="Marc_Van_Montagu" title="Marc Van Montagu">Marc Van Montagu</a> and <a href="Jeff_Schell" class="mw-redirect" title="Jeff Schell">Jeff Schell</a>, was the first company to genetically engineer insect-resistant plants by incorporating genes that produced insecticidal proteins from <a href="Bacillus_thuringiensis" title="Bacillus thuringiensis">Bacillus thuringiensis</a> (Bt) into <a href="Tobacco" title="Tobacco">tobacco</a>.<a href="#cite_note-49">[49]</a> The People's Republic of China was the first country to commercialise transgenic plants, introducing a virus-resistant tobacco in 1992.<a href="#cite_note-James1997-50">[50]</a> In 1994 <a href="Monsanto#Spin-offs_and_mergers" title="Monsanto">Calgene</a> attained approval to commercially release the <a href="Flavr_Savr" title="Flavr Savr">Flavr Savr</a> tomato, a tomato engineered to have a longer shelf life.<a href="#cite_note-doi10.3733/ca.v054n04p6-51">[51]</a> Also in 1994, the European Union approved tobacco engineered to be resistant to the herbicide <a href="Bromoxynil" title="Bromoxynil">bromoxynil</a>, making it the first genetically engineered crop commercialised in Europe.<a href="#cite_note-52">[52]</a> In 1995 Bt Potato was approved safe by the <a href="United_States_Environmental_Protection_Agency" title="United States Environmental Protection Agency">Environmental Protection Agency</a>, after having been approved by the FDA, making it the first pesticide producing crop to be approved in the US.<a href="#cite_note-53">[53]</a> In 1996 a total of 35 approvals had been granted to commercially grow 8 transgenic crops and one flower crop (carnation), with 8 different traits in 6 countries plus the EU.<a href="#cite_note-James_1996-48">[48]</a> By 2010, 29 countries had planted commercialised genetically modified crops and a further 31 countries had granted regulatory approval for transgenic crops to be imported.<a href="#cite_note-James2011-54">[54]</a>

GM banana cultivar QCAV-4 was approved by Australia and New Zealand in 2024. The banana resists the fungus that is fatal to the <a href="Cavendish_banana" title="Cavendish banana">Cavendish banana</a>, the dominant cultivar.<a href="#cite_note-55">[55]</a>

<div class="mw-heading mw-heading2"><h2 id="Methods">Methods</h2></div>

<div role="note" class="hatnote navigation-not-searchable">Main article: <a href="Genetic_engineering_techniques" title="Genetic engineering techniques">Genetic engineering techniques</a></div>

Genetically engineered crops have genes added or removed using <a href="Genetic_engineering" title="Genetic engineering">genetic engineering</a> techniques,<a href="#cite_note-56">[56]</a> originally including <a href="Gene_gun" title="Gene gun">gene guns</a>, <a href="Electroporation" title="Electroporation">electroporation</a>, <a href="Microinjection" title="Microinjection">microinjection</a> and <a href="Agrobacterium" title="Agrobacterium">agrobacterium</a>. More recently, <a href="CRISPR" title="CRISPR">CRISPR</a> and <a href="Transcription_activator-like_effector_nuclease" title="Transcription activator-like effector nuclease">TALEN</a> offered much more precise and convenient editing techniques.

Gene guns (also known as biolistics) "shoot" (direct high energy particles or radiations against<a href="#cite_note-57">[57]</a>) target genes into plant cells. It is the most common method. <a href="DNA" title="DNA">DNA</a> is bound to tiny particles of gold or tungsten which are subsequently shot into plant tissue or single plant cells under high pressure. The accelerated particles penetrate both the <a href="Cell_wall" title="Cell wall">cell wall</a> and <a href="Cell_membrane" title="Cell membrane">membranes</a>. The DNA separates from the metal and is integrated into plant DNA inside the <a href="Cell_nucleus" title="Cell nucleus">nucleus</a>. This method has been applied successfully for many cultivated crops, especially <a href="Monocot" class="mw-redirect" title="Monocot">monocots</a> like wheat or maize, for which <a href="Transformation_(genetics)" class="mw-redirect" title="Transformation (genetics)">transformation</a> using Agrobacterium tumefaciens has been less successful.<a href="#cite_note-58">[58]</a> The major disadvantage of this procedure is that serious damage can be done to the cellular tissue.

<a href="Agrobacterium_tumefaciens" title="Agrobacterium tumefaciens">Agrobacterium tumefaciens</a>-mediated transformation is another common technique. Agrobacteria are natural plant <a href="Parasites" class="mw-redirect" title="Parasites">parasites</a>.<a href="#cite_note-Halford-59">[59]</a> Their natural ability to transfer genes provides another engineering method. To create a suitable environment for themselves, these Agrobacteria insert their genes into plant hosts, resulting in a proliferation of modified plant cells near the soil level (<a href="Crown_gall" class="mw-redirect" title="Crown gall">crown gall</a>). The genetic information for tumor growth is encoded on a mobile, circular DNA fragment (<a href="Plasmid" title="Plasmid">plasmid</a>). When Agrobacterium infects a plant, it transfers this <a href="Ti_plasmid" title="Ti plasmid">T-DNA</a> to a random site in the plant genome. When used in genetic engineering the bacterial T-DNA is removed from the bacterial plasmid and replaced with the desired foreign gene. The bacterium is a <a href="Vector_(epidemiology)" class="mw-redirect" title="Vector (epidemiology)">vector</a>, enabling transportation of foreign genes into plants. This method works especially well for <a href="Dicotyledon" title="Dicotyledon">dicotyledonous</a> plants like potatoes, tomatoes, and tobacco. Agrobacteria infection is less successful in crops like wheat and maize.

Electroporation is used when the plant tissue does not contain cell walls. In this technique, "DNA enters the plant cells through miniature pores which are temporarily caused by electric pulses."

Microinjection is used to directly inject foreign DNA into cells.<a href="#cite_note-60">[60]</a>

Plant scientists, backed by results of modern comprehensive profiling of crop composition, point out that crops modified using GM techniques are less likely to have unintended changes than are conventionally bred crops.<a href="#cite_note-61">[61]</a><a href="#cite_note-62">[62]</a>

In research <a href="Tobacco" title="Tobacco">tobacco</a> and <a href="Arabidopsis_thaliana" title="Arabidopsis thaliana">Arabidopsis thaliana</a> are the most frequently modified plants, due to well-developed transformation methods, easy propagation and well studied genomes.<a href="#cite_note-63">[63]</a><a href="#cite_note-banjara-64">[64]</a> They serve as model organisms for other plant species.

Introducing new genes into plants requires a <a href="Promoter_(genetics)" title="Promoter (genetics)">promoter</a> specific to the area where the gene is to be expressed. For instance, to express a gene only in rice grains and not in leaves, an <a href="Endosperm" title="Endosperm">endosperm</a>-specific promoter is used. The <a href="Codons" class="mw-redirect" title="Codons">codons</a> of the gene must be optimized for the organism due to <a href="Codon_usage_bias" title="Codon usage bias">codon usage bias</a>.

<div class="mw-heading mw-heading2"><h2 id="Types_of_modifications">Types of modifications</h2></div>

<div class="mw-heading mw-heading3"><h3 id="Transgenic">Transgenic</h3></div>

<a href="Transgenesis" class="mw-redirect" title="Transgenesis">Transgenic</a> plants have genes inserted into them that are derived from another species. The inserted genes can come from species within the same <a href="Kingdom_(biology)" title="Kingdom (biology)">kingdom</a> (plant to plant), or between kingdoms (for example, bacteria to plant). In many cases the inserted DNA has to be modified slightly in order to be correctly and efficiently <a href="Gene_expression" title="Gene expression">expressed</a> in the host organism. Transgenic plants are used to express <a href="Proteins" class="mw-redirect" title="Proteins">proteins</a>, like the <a href="Delta_endotoxin" class="mw-redirect" title="Delta endotoxin">cry toxins</a> from B. thuringiensis, <a href="Herbicide" title="Herbicide">herbicide</a>-resistant genes, <a href="Antibodies" class="mw-redirect" title="Antibodies">antibodies</a>,<a href="#cite_note-65">[65]</a> and <a href="Antigens" class="mw-redirect" title="Antigens">antigens</a> for <a href="Vaccination" title="Vaccination">vaccinations</a>.<a href="#cite_note-66">[66]</a> A study led by the European Food Safety Authority (EFSA) also found viral genes in transgenic plants.<a href="#cite_note-67">[67]</a>

Transgenic carrots have been used to produce the drug <a href="Taliglucerase_alfa" title="Taliglucerase alfa">Taliglucerase alfa</a> which is used to treat <a href="Gaucher's_disease" title="Gaucher's disease">Gaucher's disease</a>.<a href="#cite_note-68">[68]</a> In the laboratory, transgenic plants have been modified to increase <a href="Photosynthesis" title="Photosynthesis">photosynthesis</a> (currently about 2% at most plants versus the theoretic potential of 9–10%).<a href="#cite_note-69">[69]</a> This is possible by changing the <a href="Rubisco" class="mw-redirect" title="Rubisco">rubisco</a> enzyme (i.e. changing <a href="C3_carbon_fixation" title="C3 carbon fixation">C3</a> plants into <a href="C4_carbon_fixation" title="C4 carbon fixation">C4</a> plants<a href="#cite_note-70">[70]</a>), by placing the rubisco in a <a href="Carboxysome" title="Carboxysome">carboxysome</a>, by adding CO2 pumps in the cell wall,<a href="#cite_note-pmid17578868-71">[71]</a> or by changing the leaf form or size.<a href="#cite_note-pmid20460583-72">[72]</a><a href="#cite_note-73">[73]</a><a href="#cite_note-74">[74]</a> Plants have been engineered to exhibit <a href="Bioluminescence" title="Bioluminescence">bioluminescence</a> that may become a sustainable alternative to electric lighting.<a href="#cite_note-75">[75]</a>

<div class="mw-heading mw-heading3"><h3 id="Cisgenic">Cisgenic</h3></div>

<a href="Cisgenesis" title="Cisgenesis">Cisgenic</a> plants are made using genes found within the same species or a sexually compatible closely related one, where conventional <a href="Plant_breeding" title="Plant breeding">plant breeding</a> can occur.<a href="#cite_note-76">[76]</a> Some breeders and scientists argue that cisgenic modification is useful for plants that are difficult to <a href="Crossbreed" title="Crossbreed">crossbreed</a> by conventional means (such as <a href="Potatoes" class="mw-redirect" title="Potatoes">potatoes</a>), and that plants in the cisgenic category should not require the same regulatory scrutiny as transgenics.<a href="#cite_note-77">[77]</a>

<div class="mw-heading mw-heading3"><h3 id="Subgenic">Subgenic</h3></div>

Genetically modified plants can also be developed using <a href="Gene_knockdown" title="Gene knockdown">gene knockdown</a> or <a href="Gene_knockout" title="Gene knockout">gene knockout</a> to alter the genetic makeup of a plant without incorporating genes from other plants. In 2014, Chinese researcher Gao Caixia filed patents on the creation of a strain of <a href="Wheat" title="Wheat">wheat</a> that is resistant to <a href="Powdery_mildew" title="Powdery mildew">powdery mildew</a>. The strain lacks genes that encode proteins that repress defenses against the mildew. The researchers deleted all three copies of the genes from wheat's <a href="Hexaploid" class="mw-redirect" title="Hexaploid">hexaploid</a> genome. Gao used the <a href="Transcription_activator-like_effector_nuclease" title="Transcription activator-like effector nuclease">TALENs</a> and <a href="CRISPR" title="CRISPR">CRISPR</a> <a href="Genome_editing" title="Genome editing">gene editing</a> tools without adding or changing any other genes. No field trials were immediately planned.<a href="#cite_note-tr1407-78">[78]</a><a href="#cite_note-79">[79]</a> The CRISPR technique has also been used by Penn State researcher Yinong Yang to modify white button mushrooms (<a href="Agaricus_bisporus" title="Agaricus bisporus">Agaricus bisporus</a>) to be non-browning,<a href="#cite_note-80">[80]</a> and by <a href="DuPont_Pioneer" class="mw-redirect" title="DuPont Pioneer">DuPont Pioneer</a> to make a new variety of corn.<a href="#cite_note-81">[81]</a>

<div class="mw-heading mw-heading3"><h3 id="Multiple_trait_integration">Multiple trait integration</h3></div>

With multiple trait integration, several new traits may be integrated into a new crop.<a href="#cite_note-82">[82]</a>

<div class="mw-heading mw-heading2"><h2 id="Economics">Economics</h2></div>

GM food's economic value to farmers is one of its major benefits, including in developing nations.<a href="#cite_note-83">[83]</a><a href="#cite_note-84">[84]</a><a href="#cite_note-Sustainability2011-85">[85]</a> A 2010 study found that Bt corn provided economic benefits of $6.9 billion over the previous 14 years in five Midwestern states. The majority ($4.3 billion) accrued to farmers producing non-Bt corn. This was attributed to European corn borer populations reduced by exposure to Bt corn, leaving fewer to attack conventional corn nearby.<a href="#cite_note-pmid20929774-86">[86]</a><a href="#cite_note-87">[87]</a> Agriculture economists calculated that "world surplus [increased by] $240.3 million for 1996. Of this total, the largest share (59%) went to U.S. farmers. Seed company Monsanto received the next largest share (21%), followed by US consumers (9%), the rest of the world (6%), and the germplasm supplier, <a href="Delta_%26_Pine_Land_Company_of_Mississippi" title="Delta & Pine Land Company of Mississippi">Delta & Pine Land Company of Mississippi</a> (5%)."<a href="#cite_note-88">[88]</a>

According to the <a href="International_Service_for_the_Acquisition_of_Agri-biotech_Applications" title="International Service for the Acquisition of Agri-biotech Applications">International Service for the Acquisition of Agri-biotech Applications</a> (ISAAA), in 2014 approximately 18 million farmers grew biotech crops in 28 countries; about 94% of the farmers were resource-poor in developing countries. 53% of the global biotech crop area of 181.5 million hectares was grown in 20 developing countries.<a href="#cite_note-James2014-89">[89]</a> PG Economics comprehensive 2012 study concluded that GM crops increased farm incomes worldwide by $14 billion in 2010, with over half this total going to farmers in developing countries.<a href="#cite_note-PGEconomics-90">[90]</a>

Forgoing these benefits is costly.<a href="#cite_note-Eenennaam-et-al-2021-91">[91]</a><a href="#cite_note-Zilberman-et-al-2015-92">[92]</a> Wesseler et al., 2017 estimate the cost of delay for several crops including GM banana in <a href="Uganda" title="Uganda">Uganda</a>, <a href="Genetically_modified_cowpea" class="mw-redirect" title="Genetically modified cowpea">GM cowpea</a> in <a href="West_Africa" title="West Africa">west Africa</a>, and <a href="Genetically_modified_maize" title="Genetically modified maize">GM maize/corn</a> in <a href="Kenya" title="Kenya">Kenya</a>.<a href="#cite_note-Eenennaam-et-al-2021-91">[91]</a> They estimate Nigeria alone loses $33–46m annually.<a href="#cite_note-Eenennaam-et-al-2021-91">[91]</a> The potential and alleged harms of GM crops must then be compared to these costs of delay.<a href="#cite_note-Eenennaam-et-al-2021-91">[91]</a><a href="#cite_note-Zilberman-et-al-2015-92">[92]</a>

Critics challenged the claimed benefits to farmers over the prevalence of biased observers and by the absence of <a href="Randomized_controlled_trial" title="Randomized controlled trial">randomized controlled trials</a>. The main Bt crop grown by small farmers in developing countries is cotton. A 2006 review of Bt cotton findings by agricultural economists concluded, "the overall balance sheet, though promising, is mixed. Economic returns are highly variable over years, farm type, and geographical location".<a href="#cite_note-Smale_2006-93">[93]</a>

In 2013 the European Academies Science Advisory Council (EASAC) asked the EU to allow the development of agricultural GM technologies to enable more sustainable agriculture, by employing fewer land, water, and nutrient resources. EASAC also criticizes the EU's "time-consuming and expensive regulatory framework" and said that the EU had fallen behind in the adoption of GM technologies.<a href="#cite_note-easac-94">[94]</a>

Participants in agriculture business markets include seed companies, agrochemical companies, distributors, farmers, grain elevators and universities that develop new crops/traits and whose agricultural extensions advise farmers on best practices. According to a 2012 review based on data from the late 1990s and early 2000s, much of the GM crop grown each year is used for livestock feed and increased demand for meat leads to increased demand for GM feed crops.<a href="#cite_note-Rajib-95">[95]</a> Feed grain usage as a percentage of total crop production is 70% for corn and more than 90% of oil seed meals such as soybeans. About 65 million metric tons of GM corn grains and about 70 million metric tons of soybean meals derived from GM soybean become feed.<a href="#cite_note-Rajib-95">[95]</a>

In 2014 the global value of biotech seed was US$15.7 billion; US$11.3 billion (72%) was in industrial countries and US$4.4 billion (28%) was in the developing countries.<a href="#cite_note-James2014-89">[89]</a> In 2009, <a href="Monsanto" title="Monsanto">Monsanto</a> had $7.3 billion in sales of seeds and from licensing its technology; DuPont, through its <a href="DuPont_Pioneer" class="mw-redirect" title="DuPont Pioneer">Pioneer</a> subsidiary, was the next biggest company in that market.<a href="#cite_note-ForbesPlanet-96">[96]</a> As of 2009, the overall Roundup line of products including the GM seeds represented about 50% of Monsanto's business.<a href="#cite_note-97">[97]</a>

Some patents on GM traits have expired, allowing the legal development of generic strains that include these traits. For example, generic glyphosate-tolerant GM soybean is now available. Another impact is that traits developed by one vendor can be added to another vendor's proprietary strains, potentially increasing product choice and competition.<a href="#cite_note-98">[98]</a> The patent on the first type of Roundup Ready crop that Monsanto produced (soybeans) expired in 2014<a href="#cite_note-99">[99]</a> and the first harvest of off-patent soybeans occurs in the spring of 2015.<a href="#cite_note-100">[100]</a> Monsanto has broadly licensed the patent to other seed companies that include the glyphosate resistance trait in their seed products.<a href="#cite_note-101">[101]</a> About 150 companies have licensed the technology,<a href="#cite_note-102">[102]</a> including Syngenta<a href="#cite_note-103">[103]</a> and <a href="DuPont_Pioneer" class="mw-redirect" title="DuPont Pioneer">DuPont Pioneer</a>.<a href="#cite_note-104">[104]</a>

<div class="mw-heading mw-heading2"><h2 id="Yield">Yield</h2></div>

In 2014, the largest review yet concluded that GM crops' effects on farming were positive. The <a href="Meta-analysis" title="Meta-analysis">meta-analysis</a> considered all published English-language examinations of the agronomic and economic impacts between 1995 and March 2014 for three major GM crops: soybean, maize, and cotton. The study found that herbicide-tolerant crops have lower production costs, while for insect-resistant crops the reduced pesticide use was offset by higher seed prices, leaving overall production costs about the same.<a href="#cite_note-KlumperQaim-3">[3]</a><a href="#cite_note-auto-105">[105]</a>

Yields increased 9% for herbicide tolerance and 25% for insect resistant varieties. Farmers who adopted GM crops made 69% higher profits than those who did not. The review found that GM crops help farmers in developing countries, increasing yields by 14 percentage points.<a href="#cite_note-auto-105">[105]</a>

The researchers considered some studies that were not peer-reviewed and a few that did not report sample sizes. They attempted to correct for <a href="Publication_bias" title="Publication bias">publication bias</a>, by considering sources beyond <a href="Academic_journals" class="mw-redirect" title="Academic journals">academic journals</a>. The large data set allowed the study to control for potentially confounding variables such as fertilizer use. Separately, they concluded that the funding source did not influence study results.<a href="#cite_note-auto-105">[105]</a>

Under special conditions meant to reveal only genetic yield factors, many GM crops are known to actually have lower yields. This is variously due to one or both of: Yield drag, wherein the trait itself lowers yield, either by competing for synthesis <a href="Substrate_(chemistry)" title="Substrate (chemistry)">feedstock</a> or by being inserted slightly inaccurately, into the middle of a yield-relevant gene; and/or <a href="Yield_lag" class="mw-redirect" title="Yield lag">yield lag</a>, wherein it takes some time to breed the newest yield genetics into the GM lines. This does not reflect realistic field conditions however, especially leaving out <a href="Pest_pressure" class="mw-redirect" title="Pest pressure">pest pressure</a> which is often the point of the GM trait.<a href="#cite_note-UCS-106">[106]</a> See for example <a href="Roundup_Ready#Productivity_claims" title="Roundup Ready">Roundup Ready § Productivity claims</a>.

Gene editing may also increase yields non-specific to the use of any biocides/pesticides. In March 2022, field test results showed <a href="CRISPR_gene_editing" title="CRISPR gene editing">CRISPR</a>-based <a href="Gene_knockout" title="Gene knockout">gene knockout</a> of KRN2 in maize and OsKRN2 in rice increased grain yields by ~10% and ~8% without any detected negative effects.<a href="#cite_note-107">[107]</a><a href="#cite_note-108">[108]</a>

<div class="mw-heading mw-heading2"><h2 id="Traits">Traits</h2></div>

GM crops grown today, or under development, have been modified with various <a href="Phenotypic_trait" title="Phenotypic trait">traits</a>. These traits include improved <a href="Shelf_life" title="Shelf life">shelf life</a>, <a href="Plant_disease_resistance" title="Plant disease resistance">disease resistance</a>, stress resistance, <a href="Herbicide_resistance" class="mw-redirect" title="Herbicide resistance">herbicide resistance</a>, <a href="Pest_resistance" class="mw-redirect" title="Pest resistance">pest resistance</a>, production of useful goods such as biofuel or drugs, and ability to absorb toxins and for use in <a href="Bioremediation" title="Bioremediation">bioremediation</a> of pollution.

Recently, <a href="Research_and_development" title="Research and development">research and development</a> has been targeted to <a href="Crop_enhancement" class="mw-redirect" title="Crop enhancement">enhancement of crops</a> that are locally important in <a href="Developing_countries" class="mw-redirect" title="Developing countries">developing countries</a>, such as insect-resistant <a href="Cowpea" title="Cowpea">cowpea</a> for Africa<a href="#cite_note-109">[109]</a> and insect-resistant <a href="Bt_brinjal" class="mw-redirect" title="Bt brinjal">brinjal</a> (eggplant).<a href="#cite_note-110">[110]</a>

<div class="mw-heading mw-heading3"><h3 id="Extended_shelf_life">Extended shelf life</h3></div>

The first genetically modified crop approved for sale in the U.S. was the <a href="FlavrSavr" class="mw-redirect" title="FlavrSavr">FlavrSavr</a> tomato, which had a longer shelf life.<a href="#cite_note-doi10.3733/ca.v054n04p6-51">[51]</a> First sold in 1994, FlavrSavr tomato production ceased in 1997.<a href="#cite_note-fray-111">[111]</a> It is no longer on the market.

In November 2014, the USDA approved a <a href="GM_potato" class="mw-redirect" title="GM potato">GM potato</a> that prevents bruising.<a href="#cite_note-NYTsimplot-112">[112]</a><a href="#cite_note-FR_2013-113">[113]</a>

In February 2015 <a href="Arctic_Apples" title="Arctic Apples">Arctic Apples</a> were approved by the USDA,<a href="#cite_note-AAapprov-114">[114]</a> becoming the first genetically modified apple approved for US sale.<a href="#cite_note-Tennille_2015-115">[115]</a> <a href="Gene_silencing" title="Gene silencing">Gene silencing</a> was used to reduce the expression of <a href="Polyphenol_oxidase" title="Polyphenol oxidase">polyphenol oxidase (PPO)</a>, thus preventing enzymatic browning of the fruit after it has been sliced open. The trait was added to <a href="Granny_Smith" title="Granny Smith">Granny Smith</a> and <a href="Golden_Delicious" title="Golden Delicious">Golden Delicious</a> varieties.<a href="#cite_note-AAapprov-114">[114]</a><a href="#cite_note-AAmech-116">[116]</a> The trait includes a bacterial <a href="Antibiotic_resistance" class="mw-redirect" title="Antibiotic resistance">antibiotic resistance</a> gene that provides resistance to the antibiotic <a href="Kanamycin" class="mw-redirect" title="Kanamycin">kanamycin</a>. The genetic engineering involved cultivation in the presence of kanamycin, which allowed only resistant cultivars to survive. Humans consuming apples do not acquire kanamycin resistance, per arcticapple.com.<a href="#cite_note-117">[117]</a> The FDA approved the apples in March 2015.<a href="#cite_note-118">[118]</a>

<div class="mw-heading mw-heading3"><h3 id="Improved_photosynthesis">Improved photosynthesis</h3></div>

Plants use <a href="Non-photochemical_quenching" title="Non-photochemical quenching">non-photochemical quenching</a> to protect them from excessive amounts of sunlight. Plants can switch on the quenching mechanism almost instantaneously, but it takes much longer for it to switch off again. During the time that it is switched on, the amount of energy that is wasted increases.<a href="#cite_note-Krom-119">[119]</a> A genetic modification in three genes allows to correct this (in a trial with tobacco plants). As a result, yields were 14-20% higher, in terms of the weight of the dry leaves harvested. The plants had larger leaves, were taller and had more vigorous roots.<a href="#cite_note-Krom-119">[119]</a><a href="#cite_note-120">[120]</a>

Another improvement that can be made on the photosynthesis process (with <a href="C3_carbon_fixation" title="C3 carbon fixation">C3 pathway plants</a>) is on <a href="Photorespiration" title="Photorespiration">photorespiration</a>. By inserting the C4 pathway into C3 plants, productivity may increase by as much as 50% for <a href="Cereal_crop" class="mw-redirect" title="Cereal crop">cereal crops</a>, such as rice.<a href="#cite_note-121">[121]</a><a href="#cite_note-122">[122]</a><a href="#cite_note-123">[123]</a><a href="#cite_note-124">[124]</a><a href="#cite_note-125">[125]</a>

<div class="mw-heading mw-heading3"><h3 id="Improved_biosequestration_capability">Improved biosequestration capability</h3></div>

The <a href="Harnessing_Plants_Initiative" class="mw-redirect" title="Harnessing Plants Initiative">Harnessing Plants Initiative</a> focuses on creating GM plants that have increased root mass, root depth and suberin content.

<div class="mw-heading mw-heading3"><h3 id="Improved_nutritional_value">Improved nutritional value</h3></div>

<div class="mw-heading mw-heading4"><h4 id="Edible_oils">Edible oils</h4></div>

Some GM soybeans offer improved oil profiles for processing.<a href="#cite_note-126">[126]</a> <a href="Camelina_sativa" title="Camelina sativa">Camelina sativa</a> has been modified to produce plants that accumulate high levels of oils similar to <a href="Fish_oils" class="mw-redirect" title="Fish oils">fish oils</a>.<a href="#cite_note-127">[127]</a><a href="#cite_note-128">[128]</a>

<div class="mw-heading mw-heading4"><h4 id="Vitamin_enrichment">Vitamin enrichment</h4></div>

<a href="Golden_rice" title="Golden rice">Golden rice</a>, developed by the <a href="International_Rice_Research_Institute" title="International Rice Research Institute">International Rice Research Institute</a> (IRRI), provides greater amounts of <a href="Vitamin_A" title="Vitamin A">vitamin A</a> targeted at reducing <a href="Vitamin_A_deficiency" title="Vitamin A deficiency">vitamin A deficiency</a>.<a href="#cite_note-129">[129]</a><a href="#cite_note-doi10.1038/news.2011.233-130">[130]</a> As of January 2016, golden rice has not yet been grown commercially in any country.<a href="#cite_note-131">[131]</a>

<div class="mw-heading mw-heading4"><h4 id="Toxin_reduction">Toxin reduction</h4></div>

A genetically modified <a href="Cassava" title="Cassava">cassava</a> under development offers lower <a href="Cyanogen" title="Cyanogen">cyanogen</a> <a href="Glucosides" class="mw-redirect" title="Glucosides">glucosides</a> and enhanced protein and other nutrients (called BioCassava).<a href="#cite_note-132">[132]</a>

In November 2014, the USDA approved a potato that prevents bruising and produces less <a href="Acrylamide" title="Acrylamide">acrylamide</a> when fried.<a href="#cite_note-NYTsimplot-112">[112]</a><a href="#cite_note-FR_2013-113">[113]</a> They do not employ genes from non-potato species. The trait was added to the <a href="Russet_Burbank" title="Russet Burbank">Russet Burbank</a>, <a href="Ranger_Russet" title="Ranger Russet">Ranger Russet</a> and Atlantic varieties.<a href="#cite_note-NYTsimplot-112">[112]</a>

<div class="mw-heading mw-heading3"><h3 id="Stress_resistance">Stress resistance</h3></div>

Plants have been engineered to tolerate non-biological <a href="Stress_resistances" class="mw-redirect" title="Stress resistances">stressors</a>, such as <a href="Drought" title="Drought">drought</a>,<a href="#cite_note-NYTsimplot-112">[112]</a><a href="#cite_note-FR_2013-113">[113]</a><a href="#cite_note-133">[133]</a><a href="#cite_note-134">[134]</a> <a href="Frost" title="Frost">frost</a>,<a href="#cite_note-135">[135]</a> and high <a href="Soil_salinity" title="Soil salinity">soil salinity</a>.<a href="#cite_note-banjara-64">[64]</a> In 2011, Monsanto's DroughtGard maize became the first drought-resistant GM crop to receive US marketing approval.<a href="#cite_note-pmid24067764-136">[136]</a>

Drought resistance occurs by modifying the plant's genes responsible for the mechanism known as the <a href="Crassulacean_acid_metabolism" title="Crassulacean acid metabolism">crassulacean acid metabolism</a> (CAM), which allows the plants to survive despite low water levels. This holds promise for water-heavy crops such as rice, wheat, soybeans and poplar to accelerate their adaptation to water-limited environments.<a href="#cite_note-137">[137]</a><a href="#cite_note-138">[138]</a> Several salinity tolerance mechanisms have been identified in salt-tolerant crops. For example, rice, canola and tomato crops have been genetically modified to increase their tolerance to salt stress.<a href="#cite_note-139">[139]</a><a href="#cite_note-140">[140]</a>

<div class="mw-heading mw-heading3"><h3 id="Herbicides">Herbicides</h3></div>

<div class="mw-heading mw-heading4"><h4 id="Glyphosate">Glyphosate</h4></div>

The most prevalent GM trait is herbicide tolerance,<a href="#cite_note-141">[141]</a> where <a href="Glyphosate" title="Glyphosate">glyphosate</a>-tolerance is the most common.<a href="#cite_note-142">[142]</a> Glyphosate (the active ingredient in Roundup and other herbicide products) kills plants by interfering with the <a href="Shikimic_acid" title="Shikimic acid">shikimate</a> pathway in plants, which is essential for the synthesis of the <a href="Aromatic_amino_acids" class="mw-redirect" title="Aromatic amino acids">aromatic amino acids</a> <a href="Phenylalanine" title="Phenylalanine">phenylalanine</a>, <a href="Tyrosine" title="Tyrosine">tyrosine</a>, and <a href="Tryptophan" title="Tryptophan">tryptophan</a>. The shikimate pathway is not present in animals, which instead obtain aromatic amino acids from their diet. More specifically, glyphosate inhibits the enzyme <a href="EPSP_synthase" title="EPSP synthase">5-enolpyruvylshikimate-3-phosphate synthase</a> (EPSPS).

This trait was developed because the herbicides used on grain and grass crops at the time were highly toxic and not effective against narrow-leaved weeds. Thus, developing crops that could withstand spraying with glyphosate would both reduce environmental and health risks, and give an agricultural edge to the farmer.<a href="#cite_note-agbioforum1999-143">[143]</a>

Some micro-organisms have a version of EPSPS that is resistant to glyphosate inhibition. One of these was isolated from an <a href="Agrobacterium" title="Agrobacterium">Agrobacterium</a> strain CP4 (CP4 EPSPS) that was resistant to glyphosate.<a href="#cite_note-144">[144]</a><a href="#cite_note-145">[145]</a> The CP4 EPSPS gene was engineered for plant <a href="Gene_expression" title="Gene expression">expression</a> by <a href="Gene_fusion" class="mw-redirect" title="Gene fusion">fusing</a> the 5' end of the gene to a <a href="Chloroplast" title="Chloroplast">chloroplast</a> <a href="Transit_peptide" class="mw-redirect" title="Transit peptide">transit peptide</a> derived from the <a href="Petunia" title="Petunia">petunia</a> EPSPS. This transit peptide was used because it had shown previously an ability to deliver bacterial EPSPS to the chloroplasts of other plants. This CP4 EPSPS gene was <a href="Cloning#Molecular_cloning" title="Cloning">cloned</a> and <a href="Transfection" title="Transfection">transfected</a> into <a href="Soybeans" class="mw-redirect" title="Soybeans">soybeans</a>.

The <a href="Plasmid" title="Plasmid">plasmid</a> used to move the gene into soybeans was PV-GMGTO4. It contained three bacterial genes, two CP4 EPSPS genes, and a gene <a href="Encoding" class="mw-redirect" title="Encoding">encoding</a> <a href="Beta-glucuronidase" class="mw-redirect" title="Beta-glucuronidase">beta-glucuronidase</a> (GUS) from <a href="Escherichia_coli" title="Escherichia coli">Escherichia coli</a> as a marker. The DNA was injected into the soybeans using the <a href="Gene_gun" title="Gene gun">particle acceleration method</a>. Soybean cultivar A54O3 was used for the <a href="Transformation_(genetics)" class="mw-redirect" title="Transformation (genetics)">transformation</a>.

<div class="mw-heading mw-heading4"><h4 id="Bromoxynil">Bromoxynil</h4></div>

Tobacco plants have been engineered to be resistant to the herbicide <a href="Bromoxynil" title="Bromoxynil">bromoxynil</a>.<a href="#cite_note-Debora_MacKenzie-146">[146]</a>

<div class="mw-heading mw-heading4"><h4 id="Glufosinate">Glufosinate</h4></div>

Crops have been commercialized that are resistant to the herbicide <a href="Glufosinate" title="Glufosinate">glufosinate</a>, as well.<a href="#cite_note-147">[147]</a> Crops engineered for resistance to multiple herbicides to allow farmers to use a mixed group of two, three, or four different chemicals are under development to combat growing herbicide resistance.<a href="#cite_note-148">[148]</a><a href="#cite_note-149">[149]</a>

In October 2014 the US EPA registered <a href="Dow_Chemical_Company" title="Dow Chemical Company">Dow</a>'s <a href="Enlist_Duo" class="mw-redirect" title="Enlist Duo">Enlist Duo</a> maize, which is genetically modified to be resistant to both <a href="Glyphosate" title="Glyphosate">glyphosate</a> and <a href="2%2C4-D" class="mw-redirect" title="2,4-D">2,4-D</a>, in six states.<a href="#cite_note-ISAAAaad1-150">[150]</a><a href="#cite_note-151">[151]</a><a href="#cite_note-152">[152]</a> Inserting a bacterial aryloxyalkanoate dioxygenase gene, aad1 makes the corn resistant to 2,4-D.<a href="#cite_note-ISAAAaad1-150">[150]</a><a href="#cite_note-153">[153]</a> The USDA had approved maize and soybeans with the mutation in September 2014.<a href="#cite_note-154">[154]</a>

<div class="mw-heading mw-heading4"><h4 id="Dicamba">Dicamba</h4></div>

Monsanto has requested approval for a stacked strain that is tolerant of both glyphosate and <a href="Dicamba" title="Dicamba">dicamba</a>. The request includes plans for avoiding <a href="Pesticide_drift" title="Pesticide drift">herbicide drift</a> to other crops.<a href="#cite_note-Johnson_2012-155">[155]</a> Significant damage to other non-resistant crops occurred from dicamba formulations intended to reduce <a href="Volatilization" class="mw-redirect" title="Volatilization">volatilization</a> drifting when sprayed on resistant soybeans in 2017.<a href="#cite_note-156">[156]</a> The newer dicamba formulation labels specify to not spray when average wind speeds are above 10–15 miles per hour (16–24 km/h) to avoid particle drift, average wind speeds below 3 miles per hour (4.8 km/h) to avoid <a href="Temperature_inversion" class="mw-redirect" title="Temperature inversion">temperature inversions</a>, and rain or high temperatures are in the next day forecast. However, these conditions typically only occur during June and July for a few hours at a time.<a href="#cite_note-157">[157]</a><a href="#cite_note-158">[158]</a>

<div class="mw-heading mw-heading3"><h3 id="Pest_resistance">Pest resistance</h3></div>

<div class="mw-heading mw-heading4"><h4 id="Insects">Insects</h4></div>

Tobacco, corn, rice and some other crops have been engineered to express genes encoding for insecticidal proteins from <a href="Bacillus_thuringiensis" title="Bacillus thuringiensis">Bacillus thuringiensis</a> (Bt).<a href="#cite_note-news.google.co.uk-159">[159]</a><a href="#cite_note-160">[160]</a> The introduction of Bt crops during the period between 1996 and 2005 has been estimated to have reduced the total volume of insecticide active ingredient use in the United States by over 100 thousand tons. This represents a 19.4% reduction in insecticide use.<a href="#cite_note-161">[161]</a>

In the late 1990s, a <a href="Genetically_modified_potato" title="Genetically modified potato">genetically modified potato</a> that was resistant to the <a href="Colorado_potato_beetle" title="Colorado potato beetle">Colorado potato beetle</a> was withdrawn because major buyers rejected it, fearing consumer opposition.<a href="#cite_note-NYTsimplot-112">[112]</a>

<div class="mw-heading mw-heading4"><h4 id="Viruses">Viruses</h4></div>

Plant viruses are a cause of around half of the plant diseases emerging worldwide, and an estimated 10–15% of losses in crop yields.<a href="#cite_note-:1-162">[162]</a> Papaya, potatoes, and squash have been engineered to resist viral pathogens such as <a href="Cucumber_mosaic_virus" title="Cucumber mosaic virus">cucumber mosaic virus</a> which, despite its name, infects a wide variety of plants.<a href="#cite_note-163">[163]</a><a href="#cite_note-:1-162">[162]</a>

Virus resistant papaya were developed in response to a <a href="Papaya_ringspot_virus" title="Papaya ringspot virus">papaya ringspot virus</a> (PRV) outbreak in Hawaii in the late 1990s. They incorporate PRV DNA.<a href="#cite_note-mhhe-164">[164]</a><a href="#cite_note-165">[165]</a> By 2010, 80% of Hawaiian papaya plants were genetically modified.<a href="#cite_note-166">[166]</a><a href="#cite_note-167">[167]</a>

Potatoes were engineered for resistance to <a href="Potato_leaf_roll_virus" class="mw-redirect" title="Potato leaf roll virus">potato leaf roll virus</a> and <a href="Potato_virus_Y" title="Potato virus Y">Potato virus Y</a> in 1998. Poor sales led to their market withdrawal after three years.<a href="#cite_note-168">[168]</a>

Yellow squash that were resistant to at first two, then three viruses were developed, beginning in the 1990s. The viruses are watermelon, cucumber and zucchini/courgette yellow mosaic. Squash was the second GM crop to be approved by US regulators. The trait was later added to zucchini.<a href="#cite_note-169">[169]</a>

Many strains of corn have been developed in recent years to combat the spread of <a href="Maize_dwarf_mosaic_virus" title="Maize dwarf mosaic virus">Maize dwarf mosaic virus</a>, a costly virus that causes stunted growth which is carried in <a href="Johnson_grass" title="Johnson grass">Johnson grass</a> and spread by aphid insect vectors. These strands are commercially available although the resistance is not standard among GM corn variants.<a href="#cite_note-170">[170]</a>

<div class="mw-heading mw-heading3"><h3 id="By-products">By-products</h3></div>

<div class="mw-heading mw-heading4"><h4 id="Drugs">Drugs</h4></div>

In 2012, the FDA approved the first <a href="Pharming_(genetics)" title="Pharming (genetics)">plant-produced pharmaceutical</a>, a treatment for <a href="Gaucher's_Disease" class="mw-redirect" title="Gaucher's Disease">Gaucher's Disease</a>.<a href="#cite_note-171">[171]</a> Tobacco plants have been modified to produce therapeutic antibodies.<a href="#cite_note-172">[172]</a>

<div class="mw-heading mw-heading4"><h4 id="Biofuel">Biofuel</h4></div>

<a href="Algae" title="Algae">Algae</a> is under development for use in <a href="Biofuel" title="Biofuel">biofuels</a>.<a href="#cite_note-173">[173]</a> The focus of Microalgae for mass production for biofuels modifying the algae to produce more lipid has become a focus yet will take years to see results due to the cost of this process to extract lipids.<a href="#cite_note-174">[174]</a> Researchers in Singapore were working on GM <a href="Jatropha" title="Jatropha">jatropha</a> for biofuel production.<a href="#cite_note-175">[175]</a> <a href="Syngenta" title="Syngenta">Syngenta</a> has USDA approval to market a maize trademarked Enogen that has been genetically modified to convert its starch to sugar for <a href="Ethanol" title="Ethanol">ethanol</a>.<a href="#cite_note-176">[176]</a> Some trees have been <a href="Genetically_modified_tree#Lignin_alteration" title="Genetically modified tree">genetically modified</a> to either have less <a href="Lignin" title="Lignin">lignin</a>, or to express lignin with chemically labile bonds. Lignin is the critical limiting factor when using wood to make <a href="Bio-ethanol" class="mw-redirect" title="Bio-ethanol">bio-ethanol</a> because lignin limits the accessibility of <a href="Cellulose" title="Cellulose">cellulose</a> <a href="Microfibril" title="Microfibril">microfibrils</a> to <a href="Depolymerization" title="Depolymerization">depolymerization</a> by <a href="Enzyme" title="Enzyme">enzymes</a>.<a href="#cite_note-177">[177]</a> Besides with trees, the chemically labile lignin bonds are also very useful for cereal crops such as maize,<a href="#cite_note-pmid28469705-178">[178]</a><a href="#cite_note-pmid24700858-179">[179]</a>

<div class="mw-heading mw-heading4"><h4 id="Materials">Materials</h4></div>

Companies and labs are working on plants that can be used to make <a href="Bioplastic" title="Bioplastic">bioplastics</a>.<a href="#cite_note-180">[180]</a> Potatoes that produce industrially useful starches have been developed as well.<a href="#cite_note-PotatoPro-181">[181]</a> <a href="Oilseed" class="mw-redirect" title="Oilseed">Oilseed</a> can be modified to produce fatty acids for <a href="Detergent" title="Detergent">detergents</a>, substitute <a href="Fuel" title="Fuel">fuels</a> and <a href="Petrochemical" title="Petrochemical">petrochemicals</a>.

<div class="mw-heading mw-heading4"><h4 id="Non-pesticide_pest_management_products">Non-pesticide pest management products</h4></div>

Besides the modified oilcrop above, <a href="Camelina_sativa" title="Camelina sativa">Camelina sativa</a> has also been modified to produce <a href="Helicoverpa_armigera" title="Helicoverpa armigera">Helicoverpa armigera</a> <a href="Pheromone" title="Pheromone">pheromones</a> and is in progress with a <a href="Spodoptera_frugiperda" class="mw-redirect" title="Spodoptera frugiperda">Spodoptera frugiperda</a> version. The H. armigera pheromones have been tested and are effective.<a href="#cite_note-Cornell-Alliance-Sci-182">[182]</a>

<div class="mw-heading mw-heading3"><h3 id="Bioremediation">Bioremediation</h3></div>

Scientists at the University of York developed a weed (<a href="Arabidopsis_thaliana" title="Arabidopsis thaliana">Arabidopsis thaliana</a>) that contains genes from bacteria that could clean <a href="TNT_(explosive)" class="mw-redirect" title="TNT (explosive)">TNT</a> and <a href="RDX" title="RDX">RDX</a>-explosive soil contaminants in 2011.<a href="#cite_note-183">[183]</a> 16 million hectares in the US (1.5% of the total surface) are estimated to be contaminated with TNT and RDX. However A. thaliana was not tough enough for use on military test grounds.<a href="#cite_note-Growing_a_grass_that_loves_bombs-184">[184]</a> Modifications in 2016 included <a href="Panicum_virgatum" title="Panicum virgatum">switchgrass</a> and <a href="Agrostis_stolonifera" title="Agrostis stolonifera">bentgrass</a>.<a href="#cite_note-185">[185]</a>

Genetically modified plants have been used for <a href="Bioremediation" title="Bioremediation">bioremediation</a> of contaminated soils. <a href="Mercury_(element)" title="Mercury (element)">Mercury</a>, <a href="Selenium" title="Selenium">selenium</a> and organic pollutants such as <a href="Polychlorinated_biphenyl" title="Polychlorinated biphenyl">polychlorinated biphenyls</a> (PCBs).<a href="#cite_note-Growing_a_grass_that_loves_bombs-184">[184]</a><a href="#cite_note-186">[186]</a>

Marine environments are especially vulnerable since pollution such as <a href="Oil_spills" class="mw-redirect" title="Oil spills">oil spills</a> are not containable. In addition to anthropogenic pollution, millions of tons of <a href="Petroleum" title="Petroleum">petroleum</a> annually enter the marine environment from natural seepages. Despite its toxicity, a considerable fraction of petroleum oil entering marine systems is eliminated by the hydrocarbon-degrading activities of microbial communities. Particularly successful is a recently discovered group of specialists, the so-called <a href="Hydrocarbonoclastic_bacteria" title="Hydrocarbonoclastic bacteria">hydrocarbonoclastic bacteria</a> (HCCB) that may offer useful genes.<a href="#cite_note-chapter9-187">[187]</a>

<div class="mw-heading mw-heading3"><h3 id="Asexual_reproduction">Asexual reproduction</h3></div>

Crops such as <a href="Maize" title="Maize">maize</a> reproduce sexually each year. This randomizes which genes get propagated to the next generation, meaning that desirable traits can be lost. To maintain a high-quality crop, some farmers purchase seeds every year. Typically, the seed company maintains two <a href="Inbred" class="mw-redirect" title="Inbred">inbred</a> varieties and crosses them into a <a href="Hybrid_(biology)" title="Hybrid (biology)">hybrid</a> strain that is then sold. Related plants like <a href="Sorghum" title="Sorghum">sorghum</a> and gamma grass are able to perform <a href="Apomixis" title="Apomixis">apomixis</a>, a form of asexual reproduction that keeps the plant's DNA intact. This trait is apparently controlled by a single dominant gene, but traditional breeding has been unsuccessful in creating asexually-reproducing maize. Genetic engineering offers another route to this goal. Successful modification would allow farmers to replant harvested seeds that retain desirable traits, rather than relying on purchased seed.<a href="#cite_note-188">[188]</a>

<div class="mw-heading mw-heading3"><h3 id="Other">Other</h3></div>

Genetic modifications to some crops also exist, which make it easier to process the crop, i.e. by growing it in a more compact form.<a href="#cite_note-pmid31873217-189">[189]</a> Crops such as tomatoes have been modified to be seedless.<a href="#cite_note-pmid28360425-190">[190]</a> Tobacco has been modified to produce <a href="Chlorophyll_c" title="Chlorophyll c">chlorophyll c</a> in addition to <a href="Chlorophyll_a" title="Chlorophyll a">a</a> and <a href="Chlorophyll_b" title="Chlorophyll b">b</a>, increasing growth rates. The transgene was discovered in <a href="Marine_algae" class="mw-redirect" title="Marine algae">marine algae</a>, which uses it to gain energy from the blue light that is able to penetrate seawater more effectively than longer wavelengths.<a href="#cite_note-191">[191]</a><a href="#cite_note-192">[192]</a>

<div class="mw-heading mw-heading2"><h2 id="Crops">Crops</h2></div>

<div role="note" class="hatnote navigation-not-searchable">See also: <a href="List_of_genetically_modified_crops" title="List of genetically modified crops">List of genetically modified crops</a></div>

<div class="mw-heading mw-heading3"><h3 id="Herbicide_tolerance">Herbicide tolerance</h3></div>

<th>Crop

</th>

<th>Use

</th>

<th>Countries approved in

</th>

<th>First approved<a href="#cite_note-isaaa3-193">[193]</a>

</th>

<th>Notes

</th></tr>

<tr>

<td><a href="Alfalfa#Genetic_modification" title="Alfalfa">Alfalfa</a>

</td>

<td>Animal feed<a href="#cite_note-Time-194">[194]</a>

</td>

<td>US

</td>

<td>2005

</td>

<td>Approval withdrawn in 2007<a href="#cite_note-195">[195]</a> and then re-approved in 2011<a href="#cite_note-196">[196]</a>

</td></tr>

<tr>

<td rowspan="3"><a href="Genetically_modified_canola" title="Genetically modified canola">Canola</a>

</td>

<td rowspan="3">Cooking oil

<a href="Margarine" title="Margarine">Margarine</a>

<a href="Emulsion#In_food" title="Emulsion">Emulsifiers in packaged foods</a><a href="#cite_note-Time-194">[194]</a>

</td>

<td>Australia

</td>

<td>2003

</td>

<td>

</td></tr>

<tr>

<td>Canada

</td>

<td>1995

</td>

<td>

</td></tr>

<tr>

<td>US

</td>

<td>1995

</td>

<td>

</td></tr>

<tr>

<td rowspan="9"><a href="Genetically_modified_cotton" class="mw-redirect" title="Genetically modified cotton">Cotton</a>

</td>

<td rowspan="9">Fiber <a href="Cottonseed_oil" title="Cottonseed oil">Cottonseed oil</a> Animal feed<a href="#cite_note-Time-194">[194]</a>

</td>

<td>Argentina

</td>

<td>2001

</td>

<td>

</td></tr>

<tr>

<td>Australia

</td>

<td>2002

</td>

<td>

</td></tr>

<tr>

<td>Brazil

</td>

<td>2008

</td>

<td>

</td></tr>

<tr>

<td>Colombia

</td>

<td>2004

</td>

<td>

</td></tr>

<tr>

<td>Costa Rica

</td>

<td>2008

</td>

<td>

</td></tr>

<tr>

<td>Mexico

</td>

<td>2000

</td>

<td>

</td></tr>

<tr>

<td>Paraguay

</td>

<td>2013

</td>

<td>

</td></tr>

<tr>

<td>South Africa

</td>

<td>2000

</td>

<td>

</td></tr>

<tr>

<td>US

</td>

<td>1994

</td>

<td>

</td></tr>

<tr>

<td rowspan="12"><a href="Genetically_modified_maize" title="Genetically modified maize">Maize</a>

</td>

<td rowspan="12">Animal feed

<a href="High_fructose_corn_syrup" class="mw-redirect" title="High fructose corn syrup">high-fructose corn syrup</a>

<a href="Corn_starch" title="Corn starch">corn starch</a><a href="#cite_note-Time-194">[194]</a>

</td>

<td>Argentina

</td>

<td>1998

</td>

<td>

</td></tr>

<tr>

<td>Brazil

</td>

<td>2007

</td>

<td>

</td></tr>

<tr>

<td>Canada

</td>

<td>1996

</td>

<td>

</td></tr>

<tr>

<td>Colombia

</td>

<td>2007

</td>

<td>

</td></tr>

<tr>

<td>Cuba

</td>

<td>2011

</td>

<td>

</td></tr>

<tr>

<td>European Union

</td>

<td>1998

</td>

<td>Grown in Portugal, Spain, Czech Republic, Slovakia and Romania<a href="#cite_note-ISAAA_Infographic-197">[197]</a>

</td></tr>

<tr>

<td>Honduras

</td>

<td>2001

</td>

<td>

</td></tr>

<tr>

<td>Paraguay

</td>

<td>2012

</td>

<td>

</td></tr>

<tr>

<td>Philippines

</td>

<td>2002

</td>

<td>

</td></tr>

<tr>

<td>South Africa

</td>

<td>2002

</td>

<td>

</td></tr>

<tr>

<td>US

</td>

<td>1995

</td>

<td>

</td></tr>

<tr>

<td>Uruguay

</td>

<td>2003

</td>

<td>

</td></tr>

<tr>

<td rowspan="11"><a href="Genetically_modified_soybean" title="Genetically modified soybean">Soybean</a>

</td>

<td rowspan="11">Animal feed

<a href="Soybean_oil" title="Soybean oil">Soybean oil</a><a href="#cite_note-Time-194">[194]</a>

</td>

<td>Argentina

</td>

<td>1996

</td>

<td>

</td></tr>

<tr>

<td>Bolivia

</td>

<td>2005

</td>

<td>

</td></tr>

<tr>

<td>Brazil

</td>

<td>1998

</td>

<td>

</td></tr>

<tr>

<td>Canada

</td>

<td>1995

</td>

<td>

</td></tr>

<tr>

<td>Chile

</td>

<td>2007

</td>

<td>

</td></tr>

<tr>

<td>Costa Rica

</td>

<td>2001

</td>

<td>

</td></tr>

<tr>

<td>Mexico

</td>

<td>1996

</td>

<td>

</td></tr>

<tr>

<td>Paraguay

</td>

<td>2004

</td>

<td>

</td></tr>

<tr>

<td>South Africa

</td>

<td>2001

</td>

<td>

</td></tr>

<tr>

<td>US

</td>

<td>1993

</td>

<td>

</td></tr>

<tr>

<td>Uruguay

</td>

<td>1996

</td>

<td>

</td></tr>

<tr>

<td rowspan="2"><a href="Genetically_modified_sugar_beet" title="Genetically modified sugar beet">Sugar Beet</a>

</td>

</td>

<td>Canada

</td>

<td>2001

</td>

<td>

</td></tr>

<tr>

<td>US

</td>

<td>1998

</td>

<td>Commercialised 2007,<a href="#cite_note-199">[199]</a> production blocked 2010, resumed 2011.<a href="#cite_note-WSJ-198">[198]</a>

</td></tr></tbody></table>

<div class="mw-heading mw-heading3"><h3 id="Insect_resistance">Insect resistance</h3></div>

<th>Crop

</th>

<th>Use

</th>

<th>Countries approved in

</th>

<th>First approved<a href="#cite_note-isaaa3-193">[193]</a>

</th>

<th>Notes

</th></tr>

<tr>

<td rowspan="15"><a href="Genetically_modified_cotton" class="mw-redirect" title="Genetically modified cotton">Cotton</a>

</td>

<td rowspan="15">Fiber <a href="Cottonseed_oil" title="Cottonseed oil">Cottonseed oil</a> Animal feed<a href="#cite_note-Time-194">[194]</a>

</td>

<td>Argentina

</td>

<td>1998

</td>

<td>

</td></tr>

<tr>

<td>Australia

</td>

<td>2003

</td>

<td>

</td></tr>

<tr>

<td>Brazil

</td>

<td>2005

</td>

<td>

</td></tr>

<tr>

<td>Burkina Faso

</td>

<td>2009

</td>

<td>

</td></tr>

<tr>

<td>China

</td>

<td>1997

</td>

<td>

</td></tr>

<tr>

<td>Colombia

</td>

<td>2003

</td>

<td>

</td></tr>

<tr>

<td>Costa Rica

</td>

<td>2008

</td>

<td>

</td></tr>

<tr>

<td>India

</td>

<td>2002

</td>

<td>Largest producer of Bt cotton<a href="#cite_note-Facts_India-200">[200]</a>

</td></tr>

<tr>

<td>Mexico

</td>

<td>1996

</td>

<td>

</td></tr>

<tr>

<td>Myanmar

</td>

</td>

<td>

</td></tr>

<tr>

<td>Pakistan

</td>

</td>

<td>

</td></tr>

<tr>

<td>Paraguay

</td>

<td>2007

</td>

<td>

</td></tr>

<tr>

<td>South Africa

</td>

<td>1997

</td>

<td>

</td></tr>

<tr>

<td>Sudan

</td>

<td>2012

</td>

<td>

</td></tr>

<tr>

<td>US

</td>

<td>1995

</td>

<td>

</td></tr>

<tr>

<td><a href="Bt_brinjal" class="mw-redirect" title="Bt brinjal">Eggplant</a>

</td>

<td>Food

</td>

<td>Bangladesh

</td>

<td>2013

</td>

<td>12 ha planted on 120 farms in 2014<a href="#cite_note-ISAAA_Summary_14-202">[201]</a>

</td></tr>

<tr>

<td rowspan="9"><a href="Genetically_modified_maize" title="Genetically modified maize">Maize</a>

</td>

<td rowspan="9">Animal feed

<a href="High_fructose_corn_syrup" class="mw-redirect" title="High fructose corn syrup">high-fructose corn syrup</a>

<a href="Corn_starch" title="Corn starch">corn starch</a><a href="#cite_note-Time-194">[194]</a>

</td>

<td>Argentina

</td>

<td>1998

</td>

<td>

</td></tr>

<tr>

<td>Brazil

</td>

<td>2005

</td>

<td>

</td></tr>

<tr>

<td>Colombia

</td>

<td>2003

</td>

<td>

</td></tr>

<tr>

<td>Mexico

</td>

<td>1996

</td>

<td>Centre of origin for maize<a href="#cite_note-Facts_Mexico-203">[202]</a>

</td></tr>

<tr>

<td>Paraguay

</td>

<td>2007

</td>

<td>

</td></tr>

<tr>

<td>Philippines

</td>

<td>2002

</td>

<td>

</td></tr>

<tr>

<td>South Africa

</td>

<td>1997

</td>

<td>

</td></tr>

<tr>

<td>Uruguay

</td>

<td>2003

</td>

<td>

</td></tr>

<tr>

<td>US

</td>

<td>1995

</td>

<td>

</td></tr>

<tr>

<td>Poplar

</td>

<td>Tree

</td>

<td>China

</td>

<td>1998

</td>

<td>543 ha of bt poplar planted in 2014<a href="#cite_note-Facts_China-204">[203]</a>

</td></tr></tbody></table>

<div class="mw-heading mw-heading3"><h3 id="Other_modified_traits">Other modified traits</h3></div>

<th>Crop

</th>

<th>Use

</th>

<th>Trait

</th>

<th>Countries approved in

</th>

<th>First approved<a href="#cite_note-isaaa3-193">[193]</a>

</th>

<th>Notes

</th></tr>

<tr>

<td rowspan="3"><a href="Genetically_modified_canola" title="Genetically modified canola">Canola</a>

</td>

<td rowspan="3">Cooking oil

<a href="Margarine" title="Margarine">Margarine</a>

Emulsifiers in packaged foods<a href="#cite_note-Time-194">[194]</a>

</td>

<td rowspan="2">High <a href="Laurate" class="mw-redirect" title="Laurate">laurate</a> canola

</td>

<td>Canada

</td>

<td>1996

</td>

<td>

</td></tr>

<tr>

<td>US

</td>

<td>1994

</td>

<td>

</td></tr>

<tr>

<td><a href="Phytase" title="Phytase">Phytase</a> production

</td>

<td>US

</td>

<td>1998

</td>

<td>

</td></tr>

<tr>

<td rowspan="8">Carnation

</td>

<td rowspan="8">Ornamental

</td>

<td rowspan="2">Delayed <a href="Senescence" title="Senescence">senescence</a>

</td>

<td>Australia

</td>

<td>1995

</td>

<td>

</td></tr>

<tr>

<td>Norway

</td>

<td>1998

</td>

<td>

</td></tr>

<tr>

<td rowspan="6">Modified flower colour

</td>

<td>Australia

</td>

<td>1995

</td>

<td>

</td></tr>

<tr>

<td>Colombia

</td>

<td>2000

</td>

<td>In 2014 4 ha were grown in greenhouses for export<a href="#cite_note-Facts_Colombia-205">[204]</a>

</td></tr>

<tr>

<td>European Union

</td>

<td>1998

</td>

<td>Two events expired 2008, another approved 2007

</td></tr>

<tr>

<td>Japan

</td>

<td>2004

</td>

<td>

</td></tr>

<tr>

<td>Malaysia

</td>

<td>2012

</td>

<td>For ornamental purposes

</td></tr>

<tr>

<td>Norway

</td>

<td>1997

</td>

<td>

</td></tr>

<tr>

<td rowspan="4"><a href="Genetically_modified_maize" title="Genetically modified maize">Maize</a>

</td>

<td rowspan="4">Animal feed

<a href="High_fructose_corn_syrup" class="mw-redirect" title="High fructose corn syrup">high-fructose corn syrup</a>

<a href="Corn_starch" title="Corn starch">corn starch</a><a href="#cite_note-Time-194">[194]</a>

</td>

<td rowspan="2">Increased <a href="Lysine" title="Lysine">lysine</a>

</td>

<td>Canada

</td>

<td>2006

</td>

<td>

</td></tr>

<tr>

<td>US

</td>

<td>2006

</td>

<td>

</td></tr>

<tr>

<td rowspan="2"><a href="Drought_tolerance" title="Drought tolerance">Drought tolerance</a>

</td>

<td>Canada

</td>

<td>2010

</td>

<td>

</td></tr>

<tr>

<td>US

</td>

<td>2011

</td>

<td>

</td></tr>

<tr>

<td rowspan="2">Papaya

</td>

</td>

<td rowspan="2">Virus resistance

</td>

<td>China

</td>

<td>2006

</td>

<td>

</td></tr>

<tr>

<td>US

</td>

<td>1996

</td>

<td>Mostly grown in Hawaii<a href="#cite_note-Time-194">[194]</a>

</td></tr>

<tr>

<td>Petunia

</td>

<td>Ornamental

</td>

<td>Modified flower colour

</td>

<td>China

</td>

</td>

<td>

</td></tr>

<tr>

<td rowspan="3"><a href="Genetically_modified_potato" title="Genetically modified potato">Potato</a>

</td>

</td>

<td rowspan="2">Virus resistance

</td>

<td>Canada

</td>

<td>1999

</td>

<td>

</td></tr>

<tr>

<td>US

</td>

<td>1997

</td>

<td>

</td></tr>

<tr>

<td>Industrial<a href="#cite_note-theguardian1-207">[206]</a>

</td>

<td>Modified <a href="Starch" title="Starch">starch</a>

</td>

<td>US

</td>

<td>2014

</td>

<td>

</td></tr>

<tr>

</td>

<td rowspan="4">Ornamental

</td>

<td rowspan="4">Modified flower colour

</td>

<td>Australia

</td>

<td>2009

</td>

<td>Surrendered renewal

</td></tr>

<tr>

<td>Colombia

</td>

</td>

<td>Greenhouse cultivation for export only.

</td></tr>

<tr>

<td>Japan

</td>

<td>2008

</td>

<td>

</td></tr>

<tr>

<td>US

</td>

<td>2011

</td>

<td>

</td></tr>

<tr>

<td rowspan="5"><a href="Genetically_modified_soybean" title="Genetically modified soybean">Soybean</a>

</td>

<td rowspan="5">Animal feed

<a href="Soybean_oil" title="Soybean oil">Soybean oil</a><a href="#cite_note-Time-194">[194]</a>

</td>

<td rowspan="3">Increased <a href="Oleic_acid" title="Oleic acid">oleic acid</a> production

</td>

<td>Argentina

</td>

<td>2015

</td>

<td>

</td></tr>

<tr>

<td>Canada

</td>

<td>2000

</td>

<td>

</td></tr>

<tr>

<td>US

</td>

<td>1997

</td>

<td>

</td></tr>

<tr>

<td rowspan="2"><a href="Stearidonic_acid" title="Stearidonic acid">Stearidonic acid</a> production

</td>

<td>Canada

</td>

<td>2011

</td>

<td>

</td></tr>

<tr>

<td>US

</td>

<td>2011

</td>

<td>

</td></tr>

<tr>

<td>Squash

</td>

</td>

<td>Virus resistance

</td>

<td>US

</td>

<td>1994

</td>

<td>

</td></tr>

<tr>

<td>Sugar Cane

</td>

<td>Food

</td>

<td>Drought tolerance

</td>

<td>Indonesia

</td>

<td>2013

</td>

<td>Environmental certificate only

</td></tr>

<tr>

<td><a href="Tobacco" title="Tobacco">Tobacco</a>

</td>

<td>Cigarettes

</td>

<td>Nicotine reduction

</td>

<td>US

</td>

<td>2002

</td>

<td>

</td></tr></tbody></table>

<div class="mw-heading mw-heading3"><h3 id="GM_Camelina">GM Camelina</h3></div>

Several modifications of <a href="Camelina_sativa" title="Camelina sativa">Camelina sativa</a> have been done, see <a href="#Edible_oils">§Edible oils</a> and <a href="#Non-pesticide_pest_management_products">§Non-pesticide pest management products</a> above.

<div class="mw-heading mw-heading3"><h3 id="Development">Development</h3></div>

The number of USDA-approved field releases for testing grew from 4 in 1985 to 1,194 in 2002 and averaged around 800 per year thereafter. The number of sites per release and the number of gene constructs (ways that the gene of interest is packaged together with other elements) – have rapidly increased since 2005. Releases with agronomic properties (such as drought resistance) jumped from 1,043 in 2005 to 5,190 in 2013. As of September 2013, about 7,800 releases had been approved for corn, more than 2,200 for soybeans, more than 1,100 for cotton, and about 900 for potatoes. Releases were approved for herbicide tolerance (6,772 releases), insect resistance (4,809), product quality such as flavor or nutrition (4,896), agronomic properties like drought resistance (5,190), and virus/fungal resistance (2,616). The institutions with the most authorized field releases include Monsanto with 6,782, Pioneer/DuPont with 1,405, Syngenta with 565, and USDA's Agricultural Research Service with 370. As of September 2013 USDA had received proposals for releasing GM rice, squash, plum, rose, tobacco, flax, and chicory.<a href="#cite_note-ERS_2016-209">[207]</a>

<div class="mw-heading mw-heading3"><h3 id="GMO_designer_plants_for_Mars">GMO designer plants for Mars</h3></div>

Researchers at <a href="North_Carolina_State_University" title="North Carolina State University">North Carolina State University</a> are designing genetically modified plants or <a href="Seed" title="Seed">seeds</a> to ship to <a href="Mars" title="Mars">Mars</a>, that can live in <a href="Planetary_habitability" title="Planetary habitability">habitable</a> <a href="Greenhouse" title="Greenhouse">greenhouses</a> or <a href="Closed_ecological_system" title="Closed ecological system">bio-domes</a> to help build <a href="Plant_life" class="mw-redirect" title="Plant life">plant life</a> on the planet. NASA's <a href="NASA_Institute_for_Advanced_Concepts" title="NASA Institute for Advanced Concepts">NIAC</a> is sponsoring this work on designer plants/trees or <a href="Genetically_modified_plant" title="Genetically modified plant">genetically modified</a> <a href="Vegetation" title="Vegetation">vegetation</a> that could better survive on Mars. <a href="CRISPR_gene_editing" title="CRISPR gene editing">CRISPR gene editing</a> from <a href="Extremophile" title="Extremophile">extremophiles</a> on Earth is used to help withstand the harsh <a href="Martian_regolith" title="Martian regolith">Martian regolith</a> and <a href="Atmosphere_of_Mars" title="Atmosphere of Mars">atmosphere</a>, including such challenges as <a href="Ultraviolet_radiation" class="mw-redirect" title="Ultraviolet radiation">ultraviolet radiation</a>, extreme cold, low <a href="Atmospheric_pressure" title="Atmospheric pressure">atmospheric pressure</a>, <a href="Perchlorate" title="Perchlorate">perchlorates</a>, and <a href="Drought_tolerance" title="Drought tolerance">drought tolerance</a>.<a href="#cite_note-210">[208]</a> The plants and seeds could then be tested outdoors to try and start an <a href="Ecosystem" title="Ecosystem">ecosystem</a> for the full <a href="Terraforming_of_Mars#Paraterraforming_and_GMO_designer_plants" title="Terraforming of Mars">terraforming of Mars</a>.<a href="#cite_note-211">[209]</a><a href="#cite_note-212">[210]</a><a href="#cite_note-213">[211]</a><a href="#cite_note-214">[212]</a>

<div class="mw-heading mw-heading2"><h2 id="Farming_practices">Farming practices</h2></div>

<div class="mw-heading mw-heading3"><h3 id="Resistance">Resistance</h3></div>

<div class="mw-heading mw-heading4"><h4 id="Bacillus_thuringiensis">Bacillus thuringiensis</h4></div>

Constant exposure to a toxin creates <a href="Evolutionary_pressure" title="Evolutionary pressure">evolutionary pressure</a> for pests resistant to that toxin.<a href="#cite_note-215">[213]</a> Over-reliance on <a href="Glyphosate" title="Glyphosate">glyphosate</a> and a reduction in the diversity of weed management practices allowed the spread of glyphosate resistance in 14 weed species in the US,<a href="#cite_note-ERS_2016-209">[207]</a> and in soybeans.<a href="#cite_note-perry-5">[5]</a>

To reduce resistance to <a href="Bacillus_thuringiensis" title="Bacillus thuringiensis">Bacillus thuringiensis</a> (Bt) crops, the 1996 commercialization of transgenic cotton and maize came with a management strategy to prevent insects from becoming resistant. Insect resistance management plans are mandatory for Bt crops. The aim is to encourage a large population of pests so that any (recessive) resistance genes are diluted within the population. Resistance lowers evolutionary fitness in the absence of the stressor, Bt. In refuges, non-resistant strains outcompete resistant ones.<a href="#cite_note-216">[214]</a>

With sufficiently high levels of transgene expression, nearly all of the heterozygotes (S/s), i.e., the largest segment of the pest population carrying a resistance allele, will be killed before maturation, thus preventing transmission of the resistance gene to their progeny.<a href="#cite_note-217">[215]</a> Refuges (i. e., fields of nontransgenic plants) adjacent to transgenic fields increases the likelihood that homozygous resistant (s/s) individuals and any surviving heterozygotes will mate with susceptible (S/S) individuals from the refuge, instead of with other individuals carrying the resistance allele. As a result, the resistance gene frequency in the population remains lower.

Complicating factors can affect the success of the high-dose/refuge strategy. For example, if the temperature is not ideal, thermal stress can lower Bt toxin production and leave the plant more susceptible. More importantly, reduced late-season expression has been documented, possibly resulting from <a href="DNA_methylation" title="DNA methylation">DNA methylation</a> of the <a href="Promoter_(biology)" class="mw-redirect" title="Promoter (biology)">promoter</a>.<a href="#cite_note-218">[216]</a> The success of the high-dose/refuge strategy has successfully maintained the value of Bt crops. This success has depended on factors independent of management strategy, including low initial resistance allele frequencies, fitness costs associated with resistance, and the abundance of non-Bt host plants outside the refuges.<a href="#cite_note-219">[217]</a>

Companies that produce Bt seed are introducing strains with multiple Bt proteins. Monsanto did this with Bt cotton in India, where the product was rapidly adopted.<a href="#cite_note-220">[218]</a> Monsanto has also; in an attempt to simplify the process of implementing refuges in fields to comply with Insect Resistance Management(IRM) policies and prevent irresponsible planting practices; begun marketing seed bags with a set proportion of refuge (non-transgenic) seeds mixed in with the Bt seeds being sold. Coined "Refuge-In-a-Bag" (RIB), this practice is intended to increase farmer compliance with refuge requirements and reduce additional labor needed at planting from having separate Bt and refuge seed bags on hand.<a href="#cite_note-221">[219]</a> This strategy is likely to reduce the likelihood of Bt-resistance occurring for <a href="Corn_rootworm" class="mw-redirect" title="Corn rootworm">corn rootworm</a>, but may increase the risk of resistance for <a href="Lepidopteran" class="mw-redirect" title="Lepidopteran">lepidopteran</a> corn pests, such as <a href="European_corn_borer" title="European corn borer">European corn borer</a>. Increased concerns for resistance with seed mixtures include partially resistant larvae on a Bt plant being able to move to a susceptible plant to survive or cross pollination of refuge pollen on to Bt plants that can lower the amount of Bt expressed in kernels for ear feeding insects.<a href="#cite_note-Siegfried-222">[220]</a><a href="#cite_note-Devos-223">[221]</a>

<div class="mw-heading mw-heading4"><h4 id="Herbicide_resistance">Herbicide resistance</h4></div>

Best management practices (BMPs) to control weeds may help delay resistance. BMPs include applying multiple herbicides with different modes of action, rotating crops, planting weed-free seed, scouting fields routinely, cleaning equipment to reduce the transmission of weeds to other fields, and maintaining field borders.<a href="#cite_note-ERS_2016-209">[207]</a> The most widely planted GM crops are designed to tolerate herbicides. By 2006 some weed populations had evolved to tolerate some of the same herbicides. <a href="Palmer_amaranth" class="mw-redirect" title="Palmer amaranth">Palmer amaranth</a> is a weed that competes with cotton. A native of the southwestern US, it traveled east and was first found resistant to glyphosate in 2006, less than 10 years after GM cotton was introduced.<a href="#cite_note-224">[222]</a><a href="#cite_note-225">[223]</a>

<div class="mw-heading mw-heading3"><h3 id="Plant_protection">Plant protection</h3></div>

Farmers generally use less insecticide when they plant Bt-resistant crops. Insecticide use on corn farms declined from 0.21 pound per planted acre in 1995 to 0.02 pound in 2010. This is consistent with the decline in <a href="European_corn_borer" title="European corn borer">European corn borer</a> populations as a direct result of Bt corn and cotton. The establishment of minimum refuge requirements helped delay the evolution of Bt resistance. However, resistance appears to be developing to some Bt traits in some areas.<a href="#cite_note-ERS_2016-209">[207]</a> In Colombia, GM cotton has reduced insecticide usage by 25% and herbicide usage by 5%, and GM corn has reduced insecticide and herbicide usage by 66% and 13%, respectively.<a href="#cite_note-:0-226">[224]</a>

<div class="mw-heading mw-heading3"><h3 id="Tillage">Tillage</h3></div>

By leaving at least 30% of crop residue on the soil surface from harvest through planting, <a href="Conservation_tillage" class="mw-redirect" title="Conservation tillage">conservation tillage</a> reduces soil erosion from wind and water, increases water retention, and reduces <a href="Soil_retrogression_and_degradation" title="Soil retrogression and degradation">soil degradation</a> as well as water and chemical runoff. In addition, conservation tillage reduces the carbon footprint of agriculture.<a href="#cite_note-till-227">[225]</a> A 2014 review covering 12 states from 1996 to 2006, found that a 1% increase in herbicde-tolerant (HT) soybean adoption leads to a 0.21% increase in conservation tillage and a 0.3% decrease in quality-adjusted herbicide use.<a href="#cite_note-till-227">[225]</a>

<div class="mw-heading mw-heading3"><h3 id="Greenhouse_gas_emissions">Greenhouse gas emissions</h3></div>

Combined features of increased yield, decreased land use, reduced use of fertilizer and reduced farming machinery use create a feedback loop that reduces carbon emissions related to farming. These reductions have been estimated at 7.5% of total agricultural emissions in the EU or 33 millions tons of CO2<a href="#cite_note-228">[226]</a> and an estimated 8.76 million tons of CO2 in Colombia.<a href="#cite_note-:0-226">[224]</a>

<div class="mw-heading mw-heading3"><h3 id="Drought_tolerance">Drought tolerance</h3></div>

The use of drought tolerant crops can increase yield in water-scarce locations, making farming possible in new areas. The adoption of drought tolerant maize in Ghana was shown to increase yield by more than 150% and boost commercialization intensity, although it did not significantly affect farm income.<a href="#cite_note-229">[227]</a>

<div class="mw-heading mw-heading2"><h2 id="Regulation">Regulation</h2></div>

<div role="note" class="hatnote navigation-not-searchable">Main articles: <a href="Regulation_of_genetic_engineering" title="Regulation of genetic engineering">Regulation of genetic engineering</a> and <a href="Regulation_of_the_release_of_genetic_modified_organisms" class="mw-redirect" title="Regulation of the release of genetic modified organisms">Regulation of the release of genetic modified organisms</a></div>

The regulation of genetic engineering concerns the approaches taken by governments to assess and manage the risks associated with the development and release of genetically modified crops. There are differences in the regulation of GM crops between countries, with some of the most marked differences occurring between the US and Europe. Regulation varies in a given country depending on the intended use of each product. For example, a crop not intended for food use is generally not reviewed by authorities responsible for food safety.<a href="#cite_note-Wesseler-2011-230">[228]</a><a href="#cite_note-Beckmann-2011-231">[229]</a>

<div class="mw-heading mw-heading2"><h2 id="Production">Production</h2></div>

In 2013, GM crops were planted in 27 countries; 19 were developing countries and 8 were developed countries. 2013 was the second year in which developing countries grew a majority (54%) of the total GM harvest. 18 million farmers grew GM crops; around 90% were small-holding farmers in developing countries.<a href="#cite_note-James2013-1">[1]</a>

<th>Country</th>

<th>2013– GM planted area (million hectares)<a href="#cite_note-James2012-232">[230]</a></th>

<th>Biotech crops

</th></tr>

<tr>

<td>Maize, Soybean, Cotton, Canola, Sugarbeet, Alfalfa, Papaya, Squash

</td></tr>

<tr>

<td>Brazil</td>

<td>Soybean, Maize, Cotton

</td></tr>

<tr>

<td>Argentina</td>

<td>Soybean, Maize, Cotton

</td></tr>

<tr>

<td>India</td>

<td>Cotton

</td></tr>

<tr>

<td>Canada</td>

<td>Canola, Maize, Soybean, Sugarbeet

</td></tr>

<tr>

<td>Total</td>

<td>----

</td></tr></tbody></table>

The <a href="United_States_Department_of_Agriculture" title="United States Department of Agriculture">United States Department of Agriculture</a> (USDA) reports every year on the total area of GM crop varieties planted in the United States.<a href="#cite_note-233">[231]</a><a href="#cite_note-234">[232]</a> According to <a href="National_Agricultural_Statistics_Service" title="National Agricultural Statistics Service">National Agricultural Statistics Service</a>, the states published in these tables represent 81–86 percent of all corn planted area, 88–90 percent of all soybean planted area, and 81–93 percent of all upland cotton planted area (depending on the year).

Global estimates are produced by the <a href="International_Service_for_the_Acquisition_of_Agri-biotech_Applications" title="International Service for the Acquisition of Agri-biotech Applications">International Service for the Acquisition of Agri-biotech Applications</a> (ISAAA) and can be found in their annual reports, "Global Status of Commercialized Transgenic Crops".<a href="#cite_note-James2013-1">[1]</a><a href="#cite_note-James2007-235">[233]</a>

Farmers have widely adopted GM technology (see figure). Between 1996 and 2013, the total surface area of land cultivated with GM crops increased by a factor of 100, from 17,000 square kilometers (4,200,000 acres) to 1,750,000 km2 (432 million acres).<a href="#cite_note-James2013-1">[1]</a> 10% of the world's <a href="Arable_land" title="Arable land">arable land</a> was planted with GM crops in 2010.<a href="#cite_note-James2011-54">[54]</a> As of 2011, 11 different transgenic crops were grown commercially on 395 million acres (160 million hectares) in 29 countries such as the US, Brazil, Argentina, India, Canada, China, Paraguay, Pakistan, South Africa, Uruguay, Bolivia, Australia, Philippines, Myanmar, Burkina Faso, Mexico and Spain.<a href="#cite_note-James2011-54">[54]</a> One of the key reasons for this widespread adoption is the perceived economic benefit the technology brings to farmers. For example, the system of planting glyphosate-resistant seed and then applying glyphosate once plants emerged provided farmers with the opportunity to dramatically increase the yield from a given plot of land, since this allowed them to plant rows closer together. Without it, farmers had to plant rows far enough apart to control post-emergent weeds with mechanical tillage.<a href="#cite_note-HighPlainsJ-236">[234]</a> Likewise, using Bt seeds means that farmers do not have to purchase insecticides, and then invest time, fuel, and equipment in applying them. However critics have disputed whether yields are higher and whether chemical use is less, with GM crops. See <a href="Genetically_modified_food_controversies" title="Genetically modified food controversies">Genetically modified food controversies</a> article for information.

In the US, by 2014, 94% of the planted area of soybeans, 96% of cotton and 93% of corn were genetically modified varieties.<a href="#cite_note-USDA2014-237">[235]</a><a href="#cite_note-NASS2010-238">[236]</a><a href="#cite_note-USGMOCrops2009-239">[237]</a> Genetically modified soybeans carried herbicide-tolerant traits only, but maize and cotton carried both herbicide tolerance and insect protection traits (the latter largely Bt protein).<a href="#cite_note-240">[238]</a> These constitute "input-traits" that are aimed to financially benefit the producers, but may have indirect environmental benefits and cost benefits to consumers. The Grocery Manufacturers of America estimated in 2003 that 70–75% of all processed foods in the U.S. contained a GM ingredient.<a href="#cite_note-241">[239]</a>

Europe grows relatively few genetically engineered crops<a href="#cite_note-review-242">[240]</a> with the exception of Spain, where one fifth of maize is genetically engineered,<a href="#cite_note-243">[241]</a> and smaller amounts in five other countries.<a href="#cite_note-244">[242]</a> The <a href="European_Union" title="European Union">EU</a> had a 'de facto' ban on the approval of new GM crops, from 1999 until 2004.<a href="#cite_note-EU_ban_on_GMO_illegal_WTO_rules-245">[243]</a><a href="#cite_note-ICTSD:_EU-US_dispute_over_GM_ban-246">[244]</a> GM crops are now regulated by the EU.<a href="#cite_note-Food_Safety:_from_farm_to_fork-247">[245]</a> Developing countries grew 54 percent of genetically engineered crops in 2013.<a href="#cite_note-James2013-1">[1]</a>

In recent years GM crops expanded rapidly in <a href="Developing_country" title="Developing country">developing countries</a>. In 2013 approximately 18 million farmers grew 54% of worldwide GM crops in developing countries.<a href="#cite_note-James2013-1">[1]</a> 2013's largest increase was in Brazil (403,000 km2 versus 368,000 km2 in 2012). GM cotton began growing in India in 2002, reaching 110,000 km2 in 2013.<a href="#cite_note-James2013-1">[1]</a>

According to the 2013 ISAAA brief: "a total of 36 countries (35 + EU-28) have granted regulatory approvals for biotech crops for food and/or feed use and for environmental release or planting since 1994 ... a total of 2,833 regulatory approvals involving 27 GM crops and 336 GM events (NB: an "event" is a specific genetic modification in a specific species) have been issued by authorities, of which 1,321 are for food use (direct use or processing), 918 for feed use (direct use or processing) and 599 for environmental release or planting. Japan has the largest number (198), followed by the U.S.A. (165, not including "stacked" events), Canada (146), Mexico (131), South Korea (103), Australia (93), New Zealand (83), European Union (71 including approvals that have expired or under renewal process), Philippines (68), Taiwan (65), Colombia (59), China (55) and South Africa (52). Maize has the largest number (130 events in 27 countries), followed by cotton (49 events in 22 countries), potato (31 events in 10 countries), canola (30 events in 12 countries) and soybean (27 events in 26 countries).<a href="#cite_note-James2013-1">[1]</a>

<div class="mw-heading mw-heading2"><h2 id="Controversy">Controversy</h2></div>

<div role="note" class="hatnote navigation-not-searchable">Main article: <a href="Genetically_modified_food_controversies" title="Genetically modified food controversies">Genetically modified food controversies</a></div>

Direct genetic engineering has been controversial since its introduction. Most, but not all of the controversies are over GM foods rather than crops per se. GM foods are the subject of protests, vandalism, referendums, legislation, court action<a href="#cite_note-248">[246]</a> and scientific disputes. The controversies involve consumers, biotechnology companies, governmental regulators, non-governmental organizations and scientists.

Opponents have objected to GM crops on multiple grounds including environmental impacts, food safety, whether GM crops are needed to address food needs, whether they are sufficiently accessible to farmers in developing countries,<a href="#cite_note-Azadi_2016-249">[247]</a> concerns over subjecting crops to <a href="Intellectual_property" title="Intellectual property">intellectual property</a> law, and on religious grounds.<a href="#cite_note-PoW-1998-250">[248]</a> Secondary issues include labeling, the behavior of government regulators, the effects of pesticide use and pesticide tolerance.

A significant environmental concern about using genetically modified crops is possible cross-breeding with related crops, giving them advantages over naturally occurring varieties. One example is a glyphosate-resistant rice crop that crossbreeds with a weedy relative, giving the weed a competitive advantage. The transgenic hybrid had higher rates of photosynthesis, more shoots and flowers, and more seeds than the non-transgenic hybrids.<a href="#cite_note-251">[249]</a> This demonstrates the possibility of ecosystem damage by GM crop usage.

The role of <a href="Biopiracy" title="Biopiracy">biopiracy</a> in the development of GM crops is also potentially problematic, as developed countries have gotten economic gain by using the genetic resources of developing countries. In the twentieth century, the International Rice Research Institute catalogued the genomes of almost 80,000 varieties of rice from Asian farms, which has since been used to create new higher yielding varieties of rice. These new varieties create almost 655 million dollars of economic gain for Australia, USA, Canada, and New Zealand every year.<a href="#cite_note-252">[250]</a>

There is a <a href="Scientific_consensus" title="Scientific consensus">scientific consensus</a><a href="#cite_note-Nicolia2013-8">[8]</a><a href="#cite_note-FAO-9">[9]</a><a href="#cite_note-Ronald2011-10">[10]</a><a href="#cite_note-Also-11">[11]</a> that currently available food derived from GM crops poses no greater risk to human health than conventional food,<a href="#cite_note-AAAS2012-12">[12]</a><a href="#cite_note-ECom2010-13">[13]</a><a href="#cite_note-AMA2001-14">[14]</a><a href="#cite_note-LoC2015-15">[15]</a><a href="#cite_note-NAS2016-16">[16]</a> but that each GM food needs to be tested on a case-by-case basis before introduction.<a href="#cite_note-WHOFAQ-17">[17]</a><a href="#cite_note-Haslberger2003-18">[18]</a><a href="#cite_note-BMA2004-19">[19]</a> Nonetheless, members of the public are much less likely than scientists to perceive GM foods as safe.<a href="#cite_note-PEW2015-20">[20]</a><a href="#cite_note-Marris2001-21">[21]</a><a href="#cite_note-PABE-22">[22]</a><a href="#cite_note-Scott2016-23">[23]</a> The legal and regulatory status of GM foods varies by country, with some nations banning or restricting them, and others permitting them with widely differing degrees of regulation.<a href="#cite_note-loc.gov-24">[24]</a><a href="#cite_note-Bashshur-25">[25]</a><a href="#cite_note-Sifferlin-26">[26]</a><a href="#cite_note-Council_on_Foreign_Relations-27">[27]</a>

No reports of ill effects from GM food have been documented in the human population.<a href="#cite_note-AMA-253">[251]</a><a href="#cite_note-NRC2004-254">[252]</a><a href="#cite_note-Key-255">[253]</a> GM crop labeling is required in many countries, although the United States <a href="Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> does not, nor does it distinguish between approved GM and non-GM foods.<a href="#cite_note-NYTImes2012-256">[254]</a> The United States enacted a law that requires labeling regulations to be issued by July 2018. It allows indirect disclosure such as with a phone number, bar code, or web site.<a href="#cite_note-257">[255]</a>

Advocacy groups such as <a href="Center_for_Food_Safety" title="Center for Food Safety">Center for Food Safety</a>, <a href="Union_of_Concerned_Scientists" title="Union of Concerned Scientists">Union of Concerned Scientists</a>, and <a href="Greenpeace" title="Greenpeace">Greenpeace</a> claim that risks related to GM food have not been adequately examined and managed, that GM crops are not sufficiently tested and should be labelled, and that regulatory authorities and scientific bodies are too closely tied to industry. Some studies have claimed that genetically modified crops can cause harm;<a href="#cite_note-258">[256]</a><a href="#cite_note-259">[257]</a> a 2016 review that reanalyzed the data from six of these studies found that their statistical methodologies were flawed and did not demonstrate harm, and said that conclusions about GM crop safety should be drawn from "the totality of the evidence ... instead of far-fetched evidence from single studies".<a href="#cite_note-Panchin2016-260">[258]</a>

<ul><li><a href="Food_security" title="Food security">Food security</a></li></ul>

<div class="mw-heading mw-heading2"><h2 id="Notes">Notes</h2></div>

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<li id="cite_note-Economist_2014-201">^ <a href="#cite_ref-Economist_2014_201-0">a</a> <a href="#cite_ref-Economist_2014_201-1">b</a> No official public documentation available

</li>

<li id="cite_note-208"><a href="#cite_ref-208">^</a> No public documents

</li>

</ol></div></div>

<div class="mw-heading mw-heading2"><h2 id="References">References</h2></div>

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</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.isaaa.org/resources/publications/briefs/46/executivesummary/">"ISAAA 2013 Annual Report"</a>. ISAAA Brief 46-2013. 2013. Retrieved 6 August 2014. <q>Executive Summary, Global Status of Commercialized Biotech/GM Crops</q></cite>

</li>

<li id="cite_note-Pellegrino_2018-2"><a href="#cite_ref-Pellegrino_2018_2-0">^</a> <cite id="CITEREFPellegrinoBediniNutiErcoli2018" class="citation journal cs1">Pellegrino E, Bedini S, Nuti M, Ercoli L (February 2018). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814441">"Impact of genetically engineered maize on agronomic, environmental and toxicological traits: a meta-analysis of 21 years of field data"</a>. Scientific Reports. 8 (1) 3113. <a href="Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2018NatSR...8.3113P">2018NatSR...8.3113P</a>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fs41598-018-21284-2">10.1038/s41598-018-21284-2</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814441">5814441</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/29449686">29449686</a>. <q>The introduction of an EU directive to shift GM approvals from the EU commission to the member states was immediately accepted by 19 of the 28 members who opted to ban GM crops in their countries.</q></cite>

</li>

<li id="cite_note-KlumperQaim-3">^ <a href="#cite_ref-KlumperQaim_3-0">a</a> <a href="#cite_ref-KlumperQaim_3-1">b</a> <a href="#cite_ref-KlumperQaim_3-2">c</a> <cite id="CITEREFKlümperQaim2014" class="citation journal cs1">Klümper W, Qaim M (2014). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218791">"A meta-analysis of the impacts of genetically modified crops"</a>. PLOS ONE. 9 (11): e111629. <a href="Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2014PLoSO...9k1629K">2014PLoSO...9k1629K</a>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1371%2Fjournal.pone.0111629">10.1371/journal.pone.0111629</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218791">4218791</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25365303">25365303</a>.</cite> <a href="Open_access" title="open access publication – free to read"></a>

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<li id="cite_note-nytimes.com-4"><a href="#cite_ref-nytimes.com_4-0">^</a> <cite id="CITEREFPollack2010" class="citation web cs1">Pollack A (13 April 2010). <a rel="nofollow" class="external text" href="https://www.nytimes.com/2010/04/14/business/energy-environment/14crop.html?pagewanted=all&_r=0">"Study Says Overuse Threatens Gains From Modified Crops"</a>. <a href="The_New_York_Times" title="The New York Times">The New York Times</a>.</cite>

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<li id="cite_note-perry-5">^ <a href="#cite_ref-perry_5-0">a</a> <a href="#cite_ref-perry_5-1">b</a> <cite id="CITEREFPerryCilibertoHennessyMoschini2016" class="citation journal cs1">Perry ED, Ciliberto F, Hennessy DA, Moschini G (August 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020710">"Genetically engineered crops and pesticide use in U.S. maize and soybeans"</a>. Science Advances. 2 (8): e1600850. <a href="Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2016SciA....2E0850P">2016SciA....2E0850P</a>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fsciadv.1600850">10.1126/sciadv.1600850</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020710">5020710</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27652335">27652335</a>.</cite>

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<li id="cite_note-Smyth-6">^ <a href="#cite_ref-Smyth_6-0">a</a> <a href="#cite_ref-Smyth_6-1">b</a> <cite id="CITEREFSmyth2020" class="citation journal cs1">Smyth, Stuart J. (April 2020). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061863">"The human health benefits from GM crops"</a>. Plant Biotechnology Journal. 18 (4): 887–888. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fpbi.13261">10.1111/pbi.13261</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061863">7061863</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/31544299">31544299</a>.</cite>

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<li id="cite_note-7"><a href="#cite_ref-7">^</a> <cite id="CITEREFGruèreSengupta2011" class="citation journal cs1">Gruère, G.; Sengupta, D. (2011). "Bt Cotton and Farmer Suicides in India: An Evidence-based Assessment". Journal of Development Studies. 47 (2): 316–337. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1080%2F00220388.2010.492863">10.1080/00220388.2010.492863</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21506303">21506303</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:20145281">20145281</a>.</cite>

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<li id="cite_note-Nicolia2013-8">^ <a href="#cite_ref-Nicolia2013_8-0">a</a> <a href="#cite_ref-Nicolia2013_8-1">b</a> <cite id="CITEREFNicoliaManzoVeronesiRosellini2014" class="citation journal cs1">Nicolia A, Manzo A, Veronesi F, Rosellini D (March 2014). <a rel="nofollow" class="external text" href="https://www.pps.net/cms/lib/OR01913224/Centricity/Domain/3337/peer%20reviewed%20meta%20study%20on%20GMOs%20copy.pdf">"An overview of the last 10 years of genetically engineered crop safety research"</a> (PDF). Critical Reviews in Biotechnology. 34 (1): 77–88. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3109%2F07388551.2013.823595">10.3109/07388551.2013.823595</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24041244">24041244</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:9836802">9836802</a>. <q>We have reviewed the scientific literature on GE crop safety for the last 10 years that catches the scientific consensus matured since GE plants became widely cultivated worldwide, and we can conclude that the scientific research conducted so far has not detected any significant hazard directly connected with the use of GM crops. The literature about Biodiversity and the GE food/feed consumption has sometimes resulted in animated debate regarding the suitability of the experimental designs, the choice of the statistical methods or the public accessibility of data. Such debate, even if positive and part of the natural process of review by the scientific community, has frequently been distorted by the media and often used politically and inappropriately in anti-GE crops campaigns.</q></cite>

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<li id="cite_note-FAO-9">^ <a href="#cite_ref-FAO_9-0">a</a> <a href="#cite_ref-FAO_9-1">b</a> <cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.fao.org/docrep/006/Y5160E/y5160e10.htm#P3_1651The">"State of Food and Agriculture 2003–2004. Agricultural Biotechnology: Meeting the Needs of the Poor. Health and environmental impacts of transgenic crops"</a>. Food and Agriculture Organization of the United Nations. Retrieved 30 August 2019. <q>Currently available transgenic crops and foods derived from them have been judged safe to eat and the methods used to test their safety have been deemed appropriate. These conclusions represent the consensus of the scientific evidence surveyed by the ICSU (2003) and they are consistent with the views of the World Health Organization (WHO, 2002). These foods have been assessed for increased risks to human health by several national regulatory authorities (inter alia, Argentina, Brazil, Canada, China, the United Kingdom and the United States) using their national food safety procedures (ICSU). To date no verifiable untoward toxic or nutritionally deleterious effects resulting from the consumption of foods derived from genetically modified crops have been discovered anywhere in the world (GM Science Review Panel). Many millions of people have consumed foods derived from GM plants - mainly maize, soybean and oilseed rape - without any observed adverse effects (ICSU).</q></cite>

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<li id="cite_note-Ronald2011-10">^ <a href="#cite_ref-Ronald2011_10-0">a</a> <a href="#cite_ref-Ronald2011_10-1">b</a> <cite id="CITEREFRonald2011" class="citation journal cs1">Ronald P (May 2011). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120150">"Plant genetics, sustainable agriculture and global food security"</a>. Genetics. 188 (1): 11–20. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1534%2Fgenetics.111.128553">10.1534/genetics.111.128553</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120150">3120150</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21546547">21546547</a>. <q>There is broad scientific consensus that genetically engineered crops currently on the market are safe to eat. After 14 years of cultivation and a cumulative total of 2 billion acres planted, no adverse health or environmental effects have resulted from commercialization of genetically engineered crops (Board on Agriculture and Natural Resources, Committee on Environmental Impacts Associated with Commercialization of Transgenic Plants, National Research Council and Division on Earth and Life Studies 2002). Both the U.S. National Research Council and the Joint Research Centre (the European Union's scientific and technical research laboratory and an integral part of the European Commission) have concluded that there is a comprehensive body of knowledge that adequately addresses the food safety issue of genetically engineered crops (Committee on Identifying and Assessing Unintended Effects of Genetically Engineered Foods on Human Health and National Research Council 2004; European Commission Joint Research Centre 2008). These and other recent reports conclude that the processes of genetic engineering and conventional breeding are no different in terms of unintended consequences to human health and the environment (European Commission Directorate-General for Research and Innovation 2010).</q></cite>

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<li id="cite_note-Also-11">^ <a href="#cite_ref-Also_11-0">a</a> <a href="#cite_ref-Also_11-1">b</a> But see also:<cite id="CITEREFDomingoGiné_Bordonaba2011" class="citation journal cs1">Domingo JL, Giné Bordonaba J (May 2011). <a rel="nofollow" class="external text" href="http://gaiapresse.ca/images/nouvelles/28563.pdf">"A literature review on the safety assessment of genetically modified plants"</a> (PDF). Environment International. 37 (4): 734–42. <a href="Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2011EnInt..37..734D">2011EnInt..37..734D</a>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.envint.2011.01.003">10.1016/j.envint.2011.01.003</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21296423">21296423</a>. <q>In spite of this, the number of studies specifically focused on safety assessment of GM plants is still limited. However, it is important to remark that for the first time, a certain equilibrium in the number of research groups suggesting, on the basis of their studies, that a number of varieties of GM products (mainly maize and soybeans) are as safe and nutritious as the respective conventional non-GM plant, and those raising still serious concerns, was observed. Moreover, it is worth mentioning that most of the studies demonstrating that GM foods are as nutritional and safe as those obtained by conventional breeding, have been performed by biotechnology companies or associates, which are also responsible of commercializing these GM plants. Anyhow, this represents a notable advance in comparison with the lack of studies published in recent years in scientific journals by those companies.</q></cite><cite id="CITEREFKrimsky2015" class="citation journal cs1">Krimsky S (2015). "An Illusory Consensus behind GMO Health Assessment". Science, Technology, & Human Values. 40 (6): 883–914. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1177%2F0162243915598381">10.1177/0162243915598381</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:40855100">40855100</a>. <q>I began this article with the testimonials from respected scientists that there is literally no scientific controversy over the health effects of GMOs. My investigation into the scientific literature tells another story.</q></cite>And contrast:<cite id="CITEREFPanchinTuzhikov2017" class="citation journal cs1">Panchin AY, Tuzhikov AI (March 2017). "Published GMO studies find no evidence of harm when corrected for multiple comparisons". Critical Reviews in Biotechnology. 37 (2): 213–217. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3109%2F07388551.2015.1130684">10.3109/07388551.2015.1130684</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26767435">26767435</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:11786594">11786594</a>. <q>Here, we show that a number of articles some of which have strongly and negatively influenced the public opinion on GM crops and even provoked political actions, such as GMO embargo, share common flaws in the statistical evaluation of the data. Having accounted for these flaws, we conclude that the data presented in these articles does not provide any substantial evidence of GMO harm. The presented articles suggesting possible harm of GMOs received high public attention. However, despite their claims, they actually weaken the evidence for the harm and lack of substantial equivalency of studied GMOs. We emphasize that with over 1783 published articles on GMOs over the last 10 years it is expected that some of them should have reported undesired differences between GMOs and conventional crops even if no such differences exist in reality.</q></cite>and<cite id="CITEREFYangChen2016" class="citation journal cs1">Yang YT, Chen B (April 2016). "Governing GMOs in the USA: science, law and public health". Journal of the Science of Food and Agriculture. 96 (6): 1851–5. <a href="Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2016JSFA...96.1851Y">2016JSFA...96.1851Y</a>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fjsfa.7523">10.1002/jsfa.7523</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26536836">26536836</a>. <q>It is therefore not surprising that efforts to require labeling and to ban GMOs have been a growing political issue in the USA (citing Domingo and Bordonaba, 2011). Overall, a broad scientific consensus holds that currently marketed GM food poses no greater risk than conventional food ... Major national and international science and medical associations have stated that no adverse human health effects related to GMO food have been reported or substantiated in peer-reviewed literature to date. Despite various concerns, today, the American Association for the Advancement of Science, the World Health Organization, and many independent international science organizations agree that GMOs are just as safe as other foods. Compared with conventional breeding techniques, genetic engineering is far more precise and, in most cases, less likely to create an unexpected outcome.</q></cite>

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<li id="cite_note-AAAS2012-12">^ <a href="#cite_ref-AAAS2012_12-0">a</a> <a href="#cite_ref-AAAS2012_12-1">b</a> <cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.aaas.org/sites/default/files/AAAS_GM_statement.pdf">"Statement by the AAAS Board of Directors On Labeling of Genetically Modified Foods"</a> (PDF). American Association for the Advancement of Science. 20 October 2012. Retrieved 30 August 2019. <q>The EU, for example, has invested more than €300 million in research on the biosafety of GMOs. Its recent report states: "The main conclusion to be drawn from the efforts of more than 130 research projects, covering a period of more than 25 years of research and involving more than 500 independent research groups, is that biotechnology, and in particular GMOs, are not per se more risky than e.g. conventional plant breeding technologies." The World Health Organization, the American Medical Association, the U.S. National Academy of Sciences, the British Royal Society, and every other respected organization that has examined the evidence has come to the same conclusion: consuming foods containing ingredients derived from GM crops is no riskier than consuming the same foods containing ingredients from crop plants modified by conventional plant improvement techniques.</q></cite> <cite id="CITEREFPinholste2012" class="citation web cs1">Pinholste G (25 October 2012). <a rel="nofollow" class="external text" href="https://www.aaas.org/sites/default/files/AAAS_GM_statement.pdf">"AAAS Board of Directors: Legally Mandating GM Food Labels Could "Mislead and Falsely Alarm Consumers""</a> (PDF). American Association for the Advancement of Science. Retrieved 30 August 2019.</cite>

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<li id="cite_note-ECom2010-13">^ <a href="#cite_ref-ECom2010_13-0">a</a> <a href="#cite_ref-ECom2010_13-1">b</a> <cite id="CITEREFEuropean_Commission._Directorate-General_for_Research2010" class="citation book cs1">European Commission. Directorate-General for Research (2010). <a rel="nofollow" class="external text" href="http://ec.europa.eu/research/biosociety/pdf/a_decade_of_eu-funded_gmo_research.pdf">A decade of EU-funded GMO research (2001–2010)</a> (PDF). Directorate-General for Research and Innovation. Biotechnologies, Agriculture, Food. European Commission, European Union. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2777%2F97784">10.2777/97784</a>. <a href="ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <bdi>978-92-79-16344-9</bdi>. Retrieved 30 August 2019.</cite>

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<li id="cite_note-AMA2001-14">^ <a href="#cite_ref-AMA2001_14-0">a</a> <a href="#cite_ref-AMA2001_14-1">b</a> <cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.isaaa.org/kc/Publications/htm/articles/Position/ama.htm">"AMA Report on Genetically Modified Crops and Foods (online summary)"</a>. American Medical Association. January 2001. Retrieved 30 August 2019. <q>A report issued by the scientific council of the American Medical Association (AMA) says that no long-term health effects have been detected from the use of transgenic crops and genetically modified foods, and that these foods are substantially equivalent to their conventional counterparts." "Crops and foods produced using recombinant DNA techniques have been available for fewer than 10 years and no long-term effects have been detected to date. These foods are substantially equivalent to their conventional counterparts.</q></cite> <cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20120907023039/http://www.ama-assn.org/resources/doc/csaph/a12-csaph2-bioengineeredfoods.pdf">"Report 2 of the Council On Science and Public Health (A-12): Labeling of Bioengineered Foods"</a> (PDF). American Medical Association. 2012. Archived from <a rel="nofollow" class="external text" href="http://www.ama-assn.org/resources/doc/csaph/a12-csaph2-bioengineeredfoods.pdf">the original</a> (PDF) on 7 September 2012. Retrieved 30 August 2019. <q>Bioengineered foods have been consumed for close to 20 years, and during that time, no overt consequences on human health have been reported and/or substantiated in the peer-reviewed literature.</q></cite>

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<li id="cite_note-LoC2015-15">^ <a href="#cite_ref-LoC2015_15-0">a</a> <a href="#cite_ref-LoC2015_15-1">b</a> <cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.loc.gov/law/help/restrictions-on-gmos/usa.php#Opinion">"Restrictions on Genetically Modified Organisms: United States. Public and Scholarly Opinion"</a>. Library of Congress. 30 June 2015. Retrieved 30 August 2019. <q>Several scientific organizations in the US have issued studies or statements regarding the safety of GMOs indicating that there is no evidence that GMOs present unique safety risks compared to conventionally bred products. These include the National Research Council, the American Association for the Advancement of Science, and the American Medical Association. Groups in the US opposed to GMOs include some environmental organizations, organic farming organizations, and consumer organizations. A substantial number of legal academics have criticized the US's approach to regulating GMOs.</q></cite>

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<li id="cite_note-NAS2016-16">^ <a href="#cite_ref-NAS2016_16-0">a</a> <a href="#cite_ref-NAS2016_16-1">b</a> <cite id="CITEREFNational_Academies_Of_SciencesDivision_on_Earth_Life_Studies_EngineeringBoard_on_Agriculture_Natural_ResourcesCommittee_on_Genetically_Engineered_Crops:_Past_Experience_Future_Prospects2016" class="citation book cs1">National Academies Of Sciences; Division on Earth Life Studies Engineering; Board on Agriculture Natural Resources; Committee on Genetically Engineered Crops: Past Experience Future Prospects (2016). <a rel="nofollow" class="external text" href="http://www.nap.edu/read/23395/chapter/7#149">Genetically Engineered Crops: Experiences and Prospects</a>. The National Academies of Sciences, Engineering, and Medicine (US). p. 149. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.17226%2F23395">10.17226/23395</a>. <a href="ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <bdi>978-0-309-43738-7</bdi>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28230933">28230933</a>. Retrieved 30 August 2019. <q>Overall finding on purported adverse effects on human health of foods derived from GE crops: On the basis of detailed examination of comparisons of currently commercialized GE with non-GE foods in compositional analysis, acute and chronic animal toxicity tests, long-term data on health of livestock fed GE foods, and human epidemiological data, the committee found no differences that implicate a higher risk to human health from GE foods than from their non-GE counterparts.</q></cite>

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<li id="cite_note-WHOFAQ-17">^ <a href="#cite_ref-WHOFAQ_17-0">a</a> <a href="#cite_ref-WHOFAQ_17-1">b</a> <cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.who.int/foodsafety/areas_work/food-technology/faq-genetically-modified-food/en/">"Frequently asked questions on genetically modified foods"</a>. World Health Organization. Retrieved 30 August 2019. <q>Different GM organisms include different genes inserted in different ways. This means that individual GM foods and their safety should be assessed on a case-by-case basis and that it is not possible to make general statements on the safety of all GM foods. GM foods currently available on the international market have passed safety assessments and are not likely to present risks for human health. In addition, no effects on human health have been shown as a result of the consumption of such foods by the general population in the countries where they have been approved. Continuous application of safety assessments based on the Codex Alimentarius principles and, where appropriate, adequate post market monitoring, should form the basis for ensuring the safety of GM foods.</q></cite>

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<li id="cite_note-Haslberger2003-18">^ <a href="#cite_ref-Haslberger2003_18-0">a</a> <a href="#cite_ref-Haslberger2003_18-1">b</a> <cite id="CITEREFHaslberger2003" class="citation journal cs1">Haslberger AG (July 2003). "Codex guidelines for GM foods include the analysis of unintended effects". Nature Biotechnology. 21 (7): 739–41. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnbt0703-739">10.1038/nbt0703-739</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12833088">12833088</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:2533628">2533628</a>. <q>These principles dictate a case-by-case premarket assessment that includes an evaluation of both direct and unintended effects.</q></cite>

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<li id="cite_note-BMA2004-19">^ <a href="#cite_ref-BMA2004_19-0">a</a> <a href="#cite_ref-BMA2004_19-1">b</a> Some medical organizations, including the <a href="British_Medical_Association" title="British Medical Association">British Medical Association</a>, advocate further caution based upon the <a href="Precautionary_principle" title="Precautionary principle">precautionary principle</a>: <cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.argenbio.org/adc/uploads/pdf/bma.pdf">"Genetically modified foods and health: a second interim statement"</a> (PDF). British Medical Association. March 2004. Retrieved 30 August 2019. <q>In our view, the potential for GM foods to cause harmful health effects is very small and many of the concerns expressed apply with equal vigour to conventionally derived foods. However, safety concerns cannot, as yet, be dismissed completely on the basis of information currently available. When seeking to optimise the balance between benefits and risks, it is prudent to err on the side of caution and, above all, learn from accumulating knowledge and experience. Any new technology such as genetic modification must be examined for possible benefits and risks to human health and the environment. As with all novel foods, safety assessments in relation to GM foods must be made on a case-by-case basis. Members of the GM jury project were briefed on various aspects of genetic modification by a diverse group of acknowledged experts in the relevant subjects. The GM jury reached the conclusion that the sale of GM foods currently available should be halted and the moratorium on commercial growth of GM crops should be continued. These conclusions were based on the precautionary principle and lack of evidence of any benefit. The Jury expressed concern over the impact of GM crops on farming, the environment, food safety and other potential health effects. The Royal Society review (2002) concluded that the risks to human health associated with the use of specific viral DNA sequences in GM plants are negligible, and while calling for caution in the introduction of potential allergens into food crops, stressed the absence of evidence that commercially available GM foods cause clinical allergic manifestations. The BMA shares the view that there is no robust evidence to prove that GM foods are unsafe but we endorse the call for further research and surveillance to provide convincing evidence of safety and benefit.</q></cite>

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<li id="cite_note-259"><a href="#cite_ref-259">^</a> <cite id="CITEREFKrimsky2015" class="citation journal cs1">Krimsky S (2015). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20160207171524/http://www.tufts.edu/~skrimsky/PDF/Illusory%20Consensus%20GMOs.PDF">"An Illusory Consensus behind GMO Health Assessment"</a> (PDF). Science, Technology, & Human Values. 40 (6): 883–914. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1177%2F0162243915598381">10.1177/0162243915598381</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:40855100">40855100</a>. Archived from <a rel="nofollow" class="external text" href="http://www.tufts.edu/~skrimsky/PDF/Illusory%20Consensus%20GMOs.PDF">the original</a> (PDF) on 7 February 2016. Retrieved 9 February 2016.</cite>

</li>

<li id="cite_note-Panchin2016-260"><a href="#cite_ref-Panchin2016_260-0">^</a> <cite id="CITEREFPanchinTuzhikov2017" class="citation journal cs1">Panchin AY, Tuzhikov AI (March 2017). "Published GMO studies find no evidence of harm when corrected for multiple comparisons". Critical Reviews in Biotechnology. 37 (2): 213–217. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3109%2F07388551.2015.1130684">10.3109/07388551.2015.1130684</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26767435">26767435</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:11786594">11786594</a>.</cite>

</li>

</ol></div></div>

<div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2></div>

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<ul><li><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://ec.europa.eu/food/dyna/gm_register/index_en.cfm">"EU Register of authorised GM crops"</a>.</cite></li>

<li><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20140307142909/http://www.accessdata.fda.gov/scripts/fdcc/?set=Biocon">"Biotechnology Consultations on Food from GE Plant Varieties"</a>. Archived from <a rel="nofollow" class="external text" href="http://www.accessdata.fda.gov/scripts/fdcc/?set=Biocon">the original</a> on 7 March 2014.</cite></li>

<li><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://archive.today/20141226100509/http://www.epa.gov/pesticides/biopesticides/pips/pip_list.htm">"Current & Previously Registered Section 3 PIP Registrations"</a>. Archived from <a rel="nofollow" class="external text" href="http://www.epa.gov/pesticides/biopesticides/pips/pip_list.htm">the original</a> on 26 December 2014.</cite></li></ul>

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</style></div><div role="navigation" class="navbox" aria-labelledby="Genetic_engineering301" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Genetic_engineering301" style="font-size:114%;margin:0 4em"><a href="Genetic_engineering" title="Genetic engineering">Genetic engineering</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Genetically_modified_organism" title="Genetically modified organism">Genetically modified organisms</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Genetically_modified_maize" title="Genetically modified maize">Maize/corn</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<li><a href="Starlink_corn_recall" class="mw-redirect" title="Starlink corn recall">StarLink</a></li>

<li><a href="List_of_varieties_of_genetically_modified_maize" title="List of varieties of genetically modified maize">List of varieties of genetically modified maize/corn</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Genetically_modified_potato" title="Genetically modified potato">Potato</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Amflora" title="Amflora">Amflora</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Genetically_modified_rice" title="Genetically modified rice">Rice</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Golden_rice" title="Golden rice">Golden rice</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Genetically_modified_soybean" title="Genetically modified soybean">Soybean</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Roundup_ready_soybean" class="mw-redirect" title="Roundup ready soybean">Roundup ready soybean</a></li>

<li><a href="Vistive_Gold" title="Vistive Gold">Vistive Gold</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Genetically_modified_tomato" title="Genetically modified tomato">Tomato</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Flavr_Savr" title="Flavr Savr">Flavr Savr</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Cotton#Genetic_modification" title="Cotton">Cotton</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Bt_cotton" title="Bt cotton">Bt cotton</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Genetically_modified_wheat" title="Genetically modified wheat">Wheat</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Arctic_Apples" title="Arctic Apples">Apple</a></li>

<li><a href="Arabidopsis_thaliana" title="Arabidopsis thaliana">Arabidopsis</a></li>

<li><a href="Genetically_modified_brinjal" title="Genetically modified brinjal">Brinjal</a></li>

<li><a href="Genetically_modified_canola" title="Genetically modified canola">Canola</a></li>

<li><a href="Papaya#Genetically_engineered_cultivars" title="Papaya">Papaya</a></li>

<li><a href="SmartStax" title="SmartStax">SmartStax</a></li>

<li><a href="Genetically_modified_sugar_beet" title="Genetically modified sugar beet">Sugar beet</a></li>

<li><a href="Tobacco#Genetic_modification" title="Tobacco">Tobacco</a></li>

<li><a href="Genetically_modified_tree" title="Genetically modified tree">Trees</a></li>

<li><a href="DMH-11_Mustard" title="DMH-11 Mustard">Mustard</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Genetically_modified_animal" title="Genetically modified animal">Animals</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Genetically_modified_mammal" title="Genetically modified mammal">Mammals</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Genetically_modified_mouse" title="Genetically modified mouse">Mouse</a>

<ul><li><a href="Knockout_mouse" title="Knockout mouse">Knockout mouse</a></li>

<li><a href="Oncomouse" title="Oncomouse">Oncomouse</a></li>

<li><a href="Woolly_mouse" title="Woolly mouse">Woolly mouse</a></li></ul></li>

<li><a href="Enviropig" class="mw-redirect" title="Enviropig">Enviropig</a></li>

<li><a href="Herman_the_Bull" class="mw-redirect" title="Herman the Bull">Herman the Bull</a></li>

<li><a href="Knockout_rat" title="Knockout rat">Knockout rat</a></li>

<li><a href="Alba_(rabbit)" title="Alba (rabbit)">Rabbit</a></li>

<li><a href="Ruppy" title="Ruppy">Ruppy</a></li>

<li><a href="Romulus%2C_Remus%2C_and_Khaleesi" class="mw-redirect" title="Romulus, Remus, and Khaleesi">Wolves</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other animals</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Genetically_modified_insect" title="Genetically modified insect">Insects</a></li>

<ul><li><a href="GloFish" title="GloFish">GloFish</a></li>

<li><a href="Genetically_modified_salmon" class="mw-redirect" title="Genetically modified salmon">Salmon</a></li></ul></li>

<li><a href="Genetically_modified_bird" class="mw-redirect" title="Genetically modified bird">Birds</a></li>

<li><a href="Genetically_modified_organism#Frogs" title="Genetically modified organism">Frogs</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Genetically_modified_bacteria" title="Genetically modified bacteria">Bacteria</a> and <a href="Genetically_modified_virus" title="Genetically modified virus">viruses</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Ice-minus_bacteria" title="Ice-minus bacteria">Ice-minus bacteria</a></li>

<li><a href="Hepatitis_B_vaccine" title="Hepatitis B vaccine">Hepatitis B vaccine</a></li>

<li><a href="Oncolytic_virus" title="Oncolytic virus">Oncolytic virus</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Genetic_engineering_techniques" title="Genetic engineering techniques">Processes</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Transformation_(genetics)" class="mw-redirect" title="Transformation (genetics)">Inserting DNA</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Agrobacterium" title="Agrobacterium">Agrobacteria</a></li>

<li><a href="Gene_gun" title="Gene gun">Biolistics</a></li>

<li><a href="Electroporation" title="Electroporation">Electroporation</a></li>

<li><a href="Genetic_transduction" class="mw-redirect" title="Genetic transduction">Genetic transduction</a></li>

<li><a href="Lipofection" class="mw-redirect" title="Lipofection">Lipofection</a></li>

<li><a href="Microinjection" title="Microinjection">Microinjection</a></li>

<li><a href="Somatic_cell_nuclear_transfer" title="Somatic cell nuclear transfer">Somatic cell nuclear transfer</a></li>

<li><a href="Transfection" title="Transfection">Transfection</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Recombinant_DNA" title="Recombinant DNA">Recombinant DNA</a></li>

<li><a href="Transgenesis" class="mw-redirect" title="Transgenesis">Transgenesis</a></li>

<li><a href="Cisgenesis" title="Cisgenesis">Cisgenesis</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Uses</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">In agriculture</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Genetically_modified_food" title="Genetically modified food">Genetically modified food</a>

<ul><li><a href="Genetically_modified_food_controversies" title="Genetically modified food controversies">Controversies</a></li></ul></li>

<li><a href="Pharming_(genetics)" title="Pharming (genetics)">Pharming</a></li>

<li>Companies

<li><a href="Bayer#Bayer_CropScience" title="Bayer">Bayer</a></li>

<li><a href="Dow_AgroSciences" title="Dow AgroSciences">Dow AgroSciences</a></li>

<li><a href="DuPont_Pioneer" class="mw-redirect" title="DuPont Pioneer">DuPont Pioneer</a></li>

<li><a href="Monsanto" title="Monsanto">Monsanto</a></li>

<li><a href="Syngenta" title="Syngenta">Syngenta</a></li></ul></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">In <a href="Human_genetic_engineering" class="mw-redirect" title="Human genetic engineering">humans</a> and diagnostics</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Gene_therapy" title="Gene therapy">Gene therapy</a></li>

<li><a href="Genetic_enhancement" class="mw-redirect" title="Genetic enhancement">Genetic enhancement</a></li>

<li><a href="Genetic_testing" title="Genetic testing">Genetic testing</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">In research</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Gene_knockout" title="Gene knockout">Gene knockout</a></li>

<li><a href="Gene_knockdown" title="Gene knockdown">Gene knockdown</a></li>

<li><a href="Gene_targeting" title="Gene targeting">Gene targeting</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Related articles</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Transgene" title="Transgene">Transgene</a></li>

<li><a href="Detection_of_genetically_modified_organisms" title="Detection of genetically modified organisms">Detection of genetically modified organisms</a></li>

<li><a href="Genetic_pollution" title="Genetic pollution">Genetic pollution</a></li>

<li><a href="Genetics_in_fiction" title="Genetics in fiction">Genetics in fiction</a></li>

<li><a href="Human_enhancement" title="Human enhancement">Human enhancement</a></li>

<li><a href="Reverse_transfection" title="Reverse transfection">Reverse transfection</a></li>

<li><a href="Transhumanism" title="Transhumanism">Transhumanism</a></li>

<li><a href="Genetic_use_restriction_technology" title="Genetic use restriction technology">Genetic use restriction technology</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Regulation_of_genetic_engineering" title="Regulation of genetic engineering">Regulation</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Cartagena_Protocol_on_Biosafety" title="Cartagena Protocol on Biosafety">Cartagena Protocol on Biosafety</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Geography</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Genetic_engineering_in_Europe" class="mw-redirect" title="Genetic engineering in Europe">Europe</a></li>

<li><a href="Genetic_engineering_in_Africa" class="mw-redirect" title="Genetic engineering in Africa">Africa</a></li>

<li><a href="Genetic_engineering_in_North_America" class="mw-redirect" title="Genetic engineering in North America">North America</a> (<a href="Genetic_engineering_in_the_United_States" class="mw-redirect" title="Genetic engineering in the United States">US</a>)</li>

<li><a href="Genetic_engineering_in_South_America" class="mw-redirect" title="Genetic engineering in South America">South America</a></li>

<li><a href="Genetic_engineering_in_Oceania" class="mw-redirect" title="Genetic engineering in Oceania">Oceania</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Similar fields</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Eugenics" title="Eugenics">Eugenics</a></li>

<li><a href="Cloning" title="Cloning">Cloning</a></li>

<li><a href="Stem_cell" title="Stem cell">Stem cell research</a></li>

<li><a href="Synthetic_biology" title="Synthetic biology">Synthetic biology</a></li></ul>

</div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div>

<ul><li><a href="Biology" title="Biology">Biology</a></li>

<li><a href="Genetics" title="Genetics">Genetics</a></li>

<li><a href="Biotechnology" title="Biotechnology">Biotechnology</a></li>

<li><a href="Bioethics" title="Bioethics">Bioethics</a></li></ul>

</div></td></tr></tbody></table></div>

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